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Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS. | LitMetric

Triglycerides, independent of Ferriman Gallwey Score, is a main determinant of free testosterone index in PCOS.

F1000Res

Reproductive Immunoendocrinology Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, DKI Jakarta, 10430, Indonesia.

Published: June 2020

AI Article Synopsis

  • Polycystic Ovarian Syndrome (PCOS) is a common hormonal disorder affecting 5-20% of women in their reproductive years, characterized primarily by hyperandrogenism, although not all patients exhibit this trait.
  • A study conducted on 76 women with PCOS examined the relationship between hormone levels, lipid profiles, and free testosterone index (FTI), revealing weak to moderate correlations between triglycerides, testosterone, and SHBG with FTI.
  • Findings indicated that triglyceride levels significantly correlate with hyperandrogenism in PCOS patients, while no significant association was found with free gonadal steroids (FGS).

Article Abstract

Polycystic Ovarian Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age, affecting 5-20% of women worldwide. Hyperandrogenism, as the primary characteristic of PCOS, is not always present in every patient. The hyperandrogenic phenotype of PCOS patients is influenced by both hormonal and metabolic dysfunctions. Therefore, this study aims to determine the correlation between hormone profile, lipid profile, and clinical profile with free testosterone index in subjects with PCOS. This prospective cross-sectional study was conducted in the Dr. Cipto Mangunkusumo General Hospital between July 2014 and December 2016. The study involved 76 women with PCOS, who were classified into 2 subgroups: 39 subjects in the hyperandrogenism group and 37 subjects in the non-hyperandrogenism group. Each subject underwent physical examination, blood sample collection, and USG examination. Bivariate analysis was done using independent t-tests and Mann Whitney U-tests, while multivariate analysis was done using logistic regression. Triglyceride and testosterone level showed weak (r = 0.232, p = 0.044) and moderate (r = 0.460, p ¡ 0.001) positive correlation with FTI, while SHBG level showed moderate negative correlation (r = -0.483, p ¡ 0.001). Triglyceride was also found to be determinant of hyperandrogenism condition in PCOS patient (OR 0.02, 95% CI 0.00-0.04, p = 0.013). However, there was no significant difference observed between FGS and hyperandrogenism (p = 0.43). Triglycerides, testosterone, and SHBG were associated with hyperandrogenism in PCOS patients, while FGS showed no such association.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406175PMC
http://dx.doi.org/10.12688/f1000research.16815.1DOI Listing

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