An unusual -selectivity was observed in the arylation of γ,δ-unsaturated -carbamates involving directed lithiation, transmetallation to zinc and Negishi coupling, when a specific combination of aryl electrophile and phosphine ligand is employed. Mechanistic studies indicate that an unusual, stereospecific haptotropic rearrangement of the palladium-diene intermediate is involved.
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| http://dx.doi.org/10.1039/c8sc05058a | DOI Listing |
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