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The Role of Kt/V and Creatinine clearance on Assisting Optimization of Serum Phosphorus Levels among Patients on PD.
Kidney360
October 2024
Renal Division, Department of Medicine, Icahn School of Medicine at Mount Sinai, NY, NY, USA.
Article Synopsis
- Hyperphosphatemia is common in peritoneal dialysis (PD) patients and can lead to poor health outcomes; researchers explored whether weekly creatinine clearance (CrCl) is a better indicator of serum phosphate levels compared to urea clearance.
- A study analyzed data from 16,796 PD patients across several institutions in North and South America, adjusting for various factors like age and gender, to determine the relationship between serum phosphate levels and both CrCl and urea Kt/V.
- The findings indicated that while CrCl did not outperform urea Kt/V in predicting serum phosphate levels, incorporating CrCl into predictive models improved their overall accuracy, suggesting its importance in managing phosphate levels in PD patients.
The Physicochemical Approach to Acid-Base Balance: A Critique.
J Am Soc Nephrol
January 2025
Icahn School of Medicine at Mount Sinai, New York, New York.
Modulation of circulating levels of advanced glycation end products and its impact on intima-media thickness of both common carotid arteries: CORDIOPREV randomised controlled trial.
Cardiovasc Diabetol
October 2024
Unidad de Gestión Clinica Medicina Interna, Lipids and Atherosclerosis Unit, Maimonides Institute for Biomedical Research in Córdoba, Reina Sofia University Hospital, University of Córdoba, Avda. Menéndez Pidal s/n, 14004, Córdoba, Spain.
Background: Increasing evidence supports the role of advanced glycation end products (AGEs) in atherosclerosis in both diabetic and non-diabetic patients, suggesting that therapeutic strategies targeting AGEs may offer potential benefits in this population. The Mediterranean diet is associated with improved biomarkers and anthropometric measurements related with atherosclerosis in addition to its ability to modulate AGE metabolism. Our aim was to determine whether the reduction in atherosclerosis progression (measured by changes in intima-media thickness of both common carotid arteries (IMT-CC)), observed after consumption of a Mediterranean diet compared to a low-fat diet, is associated with a modulation of circulating AGE levels in patients with coronary heart disease (CHD).
View Article and Find Full Text PDFDoes the Maillard Reaction Formation of Dietary Advanced Glycation End Products With Frying Also Merit Study as a Pathogenic Mechanism of Fried Food Toxicity or Does This Toxicity Only Involve Lipid Peroxidation?
J Nutr
October 2024
Department of Medicine, Icahn School of Medicine at Mount Sinai, NY, United States. Electronic address:
Dietary advanced glycation end-products and their associations with body weight on a Mediterranean diet and low-fat vegan diet: a randomized, cross-over trial.
Front Nutr
August 2024
Physicians Committee for Responsible Medicine, Washington, DC, United States.
Objective: Evidence suggests that changes in dietary advanced glycation end-products (AGEs) may influence body weight, but the effects of different dietary patterns remain to be explored.The aim of this study was to compare the effects of a Mediterranean and a low-fat vegan diet on dietary AGEs and test their association with body weight.
Materials And Methods: In this randomized cross-over trial, 62 overweight adults were assigned to a Mediterranean or a low-fat vegan diet for 16-week periods in random order, separated by a 4-week washout.
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