Pseudoexfoliation syndrome (PES) is a complex and age-related systemic disorder characterized by the progressive accumulation and granular deposition of pseudoexfoliative material in various intraocular and extraocular tissues. The diagnosis of PES is so important because it is a major risk factor for complications during cataract surgery and the most frequent cause of secondary glaucoma. In addition to ocular complications, PES is related with numerous systemic abnormalities, for which the list is growing steadily. Therefore, management and monitoring of patients with PES are crucial. The aim of this paper was to review current perspectives on monitoring patients with PES and addressing management of ocular and systemic associations of this clinically important and biologically fascinating disease.
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http://dx.doi.org/10.2147/OPTH.S181444 | DOI Listing |
Clin Exp Optom
January 2025
Department of Ophthalmology, Dünyagöz Tunus Hospital, Ankara, Türkiye.
Clinical Relevance: Pseudoexfoliation syndrome (PXS) is a common age-related disorder associated with glaucoma and cataract. Despite its clinical importance, the pathogenesis of PXS is not yet fully understood.
Background: To evaluate levels of SCUBE-1 (signal peptide, CUB domain, and epidermal growth factor-like domain containing protein 1) in the serum and aqueous humour of patients with PXS in comparison with non-PXS controls.
Cureus
December 2024
Ophthalmology and Visual Science, Chiba University Graduate School of Medicine, Chiba, JPN.
Objectives This study aimed to identify the etiology and the direction of dislocation of the natural crystalline lens or intraocular lens (IOL) in IOL intrascleral fixation surgery and to determine the change in intraocular pressure (IOP) after surgery. Methods We retrospectively investigated the diagnosis, direction of lens and IOL dislocation, and IOP before and after surgery (preoperatively and one day, one week, and one month postoperatively) in 236 eyes from 228 patients who underwent IOL intrascleral fixation at Chiba University Hospital between February 2015 and September 2020. Results IOL intrascleral fixation was performed in 48 (20.
View Article and Find Full Text PDFBMC Ophthalmol
January 2025
Department of Ophthalmology, University of Health Sciences, Izmir Bozyaka Education and Research Hospital, Bahar Mah. Saim Çıkrıkcı Cad No: 59, Karabağlar, Turkey.
Background: The aim of the present study was to compare the rates of change in Ganglion Cell- Inner Plexiform Layer (GCIPL) and Retinal Nerve Fiber Layer (RNFL) thickness, as measured by Optical Coherence Tomography (OCT) Guided Progression Analysis (GPA) program in control group, Primary Open Angle Glaucoma (POAG) and Pseudoexfoliation Glaucoma (PXG) eyes.
Methods: 60 POAG and 60 PXG patients and 30 control group patients were included in the study. Patients diagnosed with glaucoma were divided into two groups as mild (Mean deviation (MD) > -6.
Sci Rep
January 2025
Ophthalmic Pathology Laboratory, L V Prasad Eye Institute, Kallam Anji Reddy Campus, 500034, Hyderabad, India.
To examine ultrastructural changes in the trabecular meshwork (TM) in patients with primary and secondary glaucoma using scanning electron microscopy (SEM). This was a qualitative descriptive hospital-based study on the ultrastructure of the TM. Pure TM samples were collected after microincisional trabeculectomy from 26 patients with primary or secondary glaucoma and 10 control samples from eye bank donor corneas.
View Article and Find Full Text PDFClin Ophthalmol
December 2024
Riga Stradins University, Department of Ophthalmology, Riga, Latvia.
Purpose: This study evaluates the discrepancies between ACV measurements obtained from the Heidelberg Anterion and Zeiss IOLMaster 700 and investigates the significance of ACV and other ocular biometry parameters.
Patients And Methods: To investigate intraocular fluid circulation, a robust formula was developed for ACV measurement using the Zeiss IOLMaster 700. A pilot study was conducted to validate this formula, which relied on WTW, CCT, and ACD.
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