Effects of acetylsalicylic acid on rats: An experimental study in azaserine-rat model.

Aim: The effect of acetylsalicylic acid (ASA) on thiol levels was studied in a rat model of azaserine carcinogenesis.

Materials And Methods: ASA and azaserine were applied to the animals to research changes in cellular sulfhydryl (-SH) content and variations in free and protein-bound molecules containing the -SH group. Such effects in rats injected with azaserine were investigated at low (200 ppm) and high (400 ppm) concentrations of ASA over a relatively short (6 months) and a relatively long (12 months) period.

Results: Changes in the hepatic, pancreatic, and renal -SH contents were also determined.

Conclusion: Compared to the other tissues studied, the liver contained the highest levels of both free and protein-bound -SH.