Study Design: Scoping review.
Introduction: Dart thrower's motion (DTM) of the wrist primarily arises from the midcarpal joint, and minimizes stress to the scapholunate interosseous ligament (SLIL). After SLIL injury or surgery, early controlled DTM may reduce the effects of prolonged immobilization, while protecting SLIL integrity.
Purpose Of The Study: To summarize the literature on the effects of DTM on the injured and surgically repaired SLIL and the extent to which various DTM orthotic designs promote SLIL recovery.
Methods: A systematic literature search was conducted within 6 databases for articles published between 2003 and March 2018. Eligible studies examined DTM in the context of SLIL injury or repair. Relevant data were extracted by 2 independent reviewers.
Results: Of 425 identified articles, 15 were eligible for inclusion. Five biomechanical studies examined the influence of DTM on the injured SLIL, whereas 5 articles described DTM orthotic designs. Also included were five articles that reported outcomes when DTM was used in the rehabilitation protocol.
Discussion: The included studies suggest limiting end ranges of DTM in the injured/repaired SLIL, while blocking orthogonal plane movements. Custom orthotic designs may accomplish this goal. DTM has been used in comprehensive therapy programs in small case studies reporting short-term and intermediate clinical outcomes.
Conclusions: Caution should be exercised with using DTM on the torn SLIL as gap increases, particularly at the end-range motion. Orthosis designs have potential to limit this motion to midrange, while allowing early movement. Further high-level research is needed to understand the influence of DTM on injured and postsurgical populations.
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http://dx.doi.org/10.1016/j.jht.2018.09.005 | DOI Listing |
J Cutan Pathol
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Department of Anatomical Pathology, Dorevitch Pathology, Heidelberg, Victoria, Australia.
Melanomas show a wide spectrum of clinical, morphological, immunohistochemical, and molecular features, which can impact treatment and prognosis. Dedifferentiated and transdifferentiated melanomas (DTM) are defined as melanomas which have lost conventional melanocytic morphologic and immunohistochemical features, showing sarcomatous morphology and/or immunohistochemical staining of other cell lineages, and as such, can be mistaken for other entities such as collision tumors and undifferentiated spindle cell tumors. In this series, we highlight the utility of preferentially expressed antigen in melanomas (PRAME) in diagnosing undifferentiated/dedifferentiated melanomas.
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Department of Anesthesiology, Louisiana State University Health Sciences Center at Shreveport, Shreveport, LA, 71103, USA.
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Recent Findings: This systematic review focuses on both residual pain levels and ability to perform daily tasks after treatment with SCS.
Pharmacoeconomics
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Schumpeter School of Business and Economics, University of Wuppertal, Wuppertal, Germany.
Objectives: For US Medicare and Medicaid, single drug prices do not reflect the value of supplemental indications. Value-based indication-specific and weighted-average pricing has been suggested for drugs with multiple indications. Under indication-specific pricing, a distinct price is assigned to the differential value a drug offers in each indication.
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Department of Medical Oncology, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing, China.
Biosensors (Basel)
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EMBIO Diagnostics Ltd., Athalassas, 2018 Nicosia, Cyprus.
The prevalence of foodborne diseases is continuously increasing, causing numerous hospitalizations and deaths, as well as money loss in the agri-food sector and food supply chain worldwide. The standard analyses currently used for bacteria detection have significant limitations with the most important being their long procedural time that can be crucial for foodborne outbreaks. In this study, a biosensor system able to perform robust and accurate detection of spp.
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