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Diagnostic challenges associated with adrenocortical neoplasms arising from adreno-hepatic fusion: a case report of two patients and a literature review.
Gland Surg
December 2024
Department of Pathology, Seoul National University Bundang Hospital, Seongnam, Korea.
Background: A right adrenal gland may present in the form of adreno-hepatic fusion (AHF), in which the adrenal cells are interspersed among the hepatocytes without septation. This rare, naturally-occurring phenomenon may be associated with preoperative misdiagnosis. We present two cases of adrenal tumor in patients with AHF that were misdiagnosed, despite thorough preoperative work-ups.
View Article and Find Full Text PDFAdrenal PEComa Treated by Surgical Resection and Postoperative Radiotherapy: A Case Report.
Am J Case Rep
December 2024
Department of Pathology, Eskişehir City Hospital, Eskişehir, Turkey.
BACKGROUND Perivascular epitheloid cell neoplasm (PEComa) is a rare mesenchymal tumor that is evaluated in the same tumor family as angiomyolipoma, sugar cell tumor of the lung, and lymphangioleiomyomatosis. Immunohistochemically, the disease can express melanocytic and myogenic markers, such as HMB45, HMSA1, MelanA/Mart1, and actin. The disease can be seen in almost every organ, especially the uterus and retroperitoneum.
View Article and Find Full Text PDFCommon incidental urological lesions on computed tomography images: What to do with renal and adrenal computed tomography incidentalomas in a primary care setting.
Aust J Gen Pract
November 2024
MBBS, PhD, FRACS (Urol), Professor, Department of Surgery, The University of Melbourne, Melbourne, Vic; Founding Director, EJ Whitten Prostate Cancer Research Centre at Epworth Healthcare, Melbourne, Vic;@Head of Unit, Department of Urology, The Royal Melbourne Hospital, Melbourne, Vic.
Article Synopsis
- The increased use of imaging techniques has led to more frequent detection of incidental findings in the kidneys and adrenal glands, often referred to as incidentalomas, which are commonly encountered by general practitioners.* -
- This review provides guidelines for managing these renal and adrenal masses, highlighting that renal lesions are seen in about 14% of CT scans and should be assessed using the Bosniak classification for cystic lesions.* -
- For renal cell carcinomas larger than 4 cm or showing symptoms, active treatment is recommended, while adrenal lesions require functional testing, with specific screening tests indicated based on clinical signs such as hypertension.*
Is It Enough to Diagnose Pheochromocytoma by Measuring Urine Metanephrines Levels?
Cureus
September 2024
Endocrinology and Metabolism, Ankara Yıldırım Beyazıt University School of Medicine, Ankara, TUR.
Article Synopsis
- - This study evaluated the effectiveness of plasma and urinary metanephrines as diagnostic tools for adrenal lesions in 152 patients, highlighting their importance in a multidisciplinary medical setting.
- - A variety of adrenal conditions were identified among patients, including pheochromocytoma and adrenocortical carcinoma, with 94 patients undergoing surgery.
- - Urinary fractionated metanephrine was found to be the most sensitive test for diagnosing pheochromocytoma (90%), while plasma free normetanephrine was the most specific (91.4%), demonstrating a significant correlation between the plasma and urinary tests.
Retroperitoneal Hemorrhage: A Rare Cause of Severe Acute Maternal Morbidity and Perinatal Mortality.
Cureus
September 2024
Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research, Chandigarh, IND.
Article Synopsis
- Retroperitoneal hemorrhage, especially from adrenal or renal tumors, can manifest in vague ways during pregnancy, making diagnosis challenging without known risk factors.* -
- Three cases of pregnant women in their third trimester showed these hemorrhages, with one having adrenal bleeding and two with renal tumor bleeding, all presenting unexpectedly without prior health issues.* -
- Quick medical response and teamwork led to successful outcomes for the mothers, and the only patient with adrenal hemorrhage had a healthy baby, while the others faced fetal loss.*
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