Oncogenes calling on a lysosomal Ca channel.

Oncogene‐dependent cancers upregulate and use lysosomal biogenesis for nutrient supply. It is unclear which lysosomal proteins and functions are essential for cell proliferation and tumor growth. A study by Jung in this issue of shows that increased levels of the lysosomal Ca release channel TRPML1 and its activator PI(3,5)P in HRAS ‐dependent tumors are essential for cell proliferation and tumor growth 1. Notably, genetic and pharmacological inhibition of TRPML1 is equally effective in suppressing HRAS ‐dependent tumors.