Ovalbumin peptides are food protein-derived fragments comprised of amino acid residues. The bioactive properties of the peptides are determined by the inherent amino acid composition and sequence of the peptide. The objective of this study was to evaluate the proteomics characteristics in Tibetan chicken egg ovalbumin peptides, compared to ordinary eggs, using isobaric tags for the relative and absolute quantification labelling technique (iTRAQ). The results showed that 165 proteins were identified and 56 proteins were significantly changed including 34 significantly upregulated and 22 significantly downregulated proteins. The more abundant proteins of the Tibetan ovalbumin peptides included vitellogenin-2, vitellogenin-1, vitellogenin, apolipoprotein A-I, and serum albumin, which were upregulated. A Gene Ontology (GO) analysis showed that these proteins mostly participated in biological processes and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis showed that they may be associated with the peroxisome proliferator-activated receptor (PPAR) pathway, which is related to lipid metabolism. The Protein-Protein Interaction (PPI) analysis showed that these proteins significantly interacted.
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http://dx.doi.org/10.1016/j.ijbiomac.2019.03.075 | DOI Listing |
Ann Med
December 2025
Department of Pulmonary and Critical Care Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Objective: The prognosis for severe asthma is poor, and the current treatment options are limited. The methyl-CpG binding domain protein 2 (MBD2) participates in neutrophil-mediated severe asthma through epigenetic regulation. Neutrophil extracellular traps (NETs) play a critical role in the pathogenesis of severe asthma.
View Article and Find Full Text PDFStem Cell Res Ther
January 2025
Department of Nuclear Medicine, The Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, Jiangsu, P. R. China.
Background: Asthma is a prevalent respiratory disease, and its management remains largely unsatisfactory. Mesenchymal stem cells (MSCs) have been demonstrated to be efficacious in reducing airway inflammation in experimental allergic diseases, representing a potential alternative treatment for asthma. Migrasomes are recently identified extracellular vesicles (EVs) generated in migrating cells and facilitate intercellular communication.
View Article and Find Full Text PDFFood Res Int
February 2025
Université de Lille, UMRT 1158 BioEcoAgro, F-59000 Lille, France. Electronic address:
Besides their nutritional role, proteins are recognized for their ability to regulate both short- and long-term energy homeostasis. However, studies investigating the effects of proteins based on their quality and origin remain limited and often lack comparability. Nonetheless, existing research consistently underscores the influence of proteins on food intake regulation.
View Article and Find Full Text PDFRedox Rep
December 2025
Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
Objectives: Asthma, a prevalent chronic disease, poses significant health threats and burdens healthcare systems. This study focused on the role of bronchial epithelial cells in asthma pathophysiology.
Methods: Bioinformatics was used to identify key asthmarelated genes.
Food Chem
January 2025
Jilin Provincial Key Laboratory of Nutrition and Functional Food and College of Food Science and Engineering, Jilin University, Changchun 130062, People's Republic of China. Electronic address:
During the preparation and development of selenium nanoparticles (SeNPs), natural bioactive peptides are added to enhance their physicochemical characteristics and functional properties. Among these properties, immunomodulatory activities, which include activating immune cells to strengthen immunity, constitute the major functions of the immune system. To obtain SeNPs with enhanced immunomodulation, ovalbumin peptide (OP) was used as a stabilizer, yielding OP-SeNPs.
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