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http://dx.doi.org/10.1016/j.ajem.2019.03.008 | DOI Listing |
Trials
January 2025
Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, UK.
Background: With the population ageing, more victims of community crime are likely to be older adults. The psychological impact of crime on older victims is significant and sustained, but only feasibility trials have been published regarding potential interventions. The integration of public health and care services and cross-agency working is recommended, but there is little information on how this should be undertaken.
View Article and Find Full Text PDFSci Rep
January 2025
School of Resources and Civil Engineering, Northeastern University, Shenyang, 110819, China.
Based on the symmetric initiation mechanism of double-wing cracks in coal rock mass induced by high-pressure electro-recoil water pressure, fracturing experiments have been performed on coal rock mass under different water pressures and discharge conditions using high-voltage electric pulse hydraulic fracturing devices. Combined with CT scans, the crack spatial distribution inside the post-break coal rock mass was analyzed and found that the edge of the water injection hole is prone to produce double-wing cracks along the drilling hole diameter. ABAQUS is used to verify the physical test and extend the test conditions, the geometric parameter change, morphological expansion rule and crack initiation mechanism of double-wing crack in coal rock mass under different discharge conditions and ground stress conditions are studied.
View Article and Find Full Text PDFTherapie
December 2024
Science Po, université Paris-Cité, 75006 Paris, France.
France has been engaged in a legal and organisational transition for many years. It has had to adapt its national framework to the legal requirements of personal data protection, European ambitions and international competition. From the Data Protection Act of 1978 to the Healthcare System Transformation Act of 2019, reforms have strengthened requirements in terms of personal data protection, while opening the way to innovative uses.
View Article and Find Full Text PDFPLoS One
January 2025
Key Laboratory for Special Area Highway Engineering of Ministry of Education, Chang'an University, Xi'an, Shaanxi, China.
The large particle size asphalt mixture with nominal maximum aggregate size 53 mm(LSAM-50) has good technical and economic performance and will become an effective technical way to build a full-thick long-life asphalt pavement with Chinese characteristics. In order to reveal the mechanical properties and influencing factors of LSAM-50 in depth, a numerical test method for the mechanical properties of the large particle size LSAM-50 asphalt mixture was developed, and a reasonable specimen size for LSAM-50 performance test was proposed by combining the numerical test and the indoor test. The results show that: LSAM-50 numerical test conditions are the calculation time step 10-3 s/step, the loading rate is 2 mm/min (uniaxial compression numerical test) and 50 mm/min (splitting numerical test) when LSAM-50 numerical experiment calculation rate and numerical experiment accuracy are better; after the size of the specimen reaches 200×160mm, the influence of the size effect is eliminated.
View Article and Find Full Text PDFHandb Exp Pharmacol
January 2025
Genentech Inc, South San Francisco, CA, USA.
In this chapter, we envision the future of Quantitative Systems Pharmacology (QSP) which integrates closely with emerging data and technologies including advanced analytics, novel experimental technologies, and diverse and larger datasets. Machine learning (ML) and Artificial Intelligence (AI) will increasingly help QSP modelers to find, prepare, integrate, and exploit larger and diverse datasets, as well as build, parameterize, and simulate models. We picture QSP models being applied during all stages of drug discovery and development: During the discovery stages, QSP models predict the early human experience of in silico compounds created by generative AI.
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