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Effect of Three Different Daily Protein Intakes in a Two-Meal Eating Pattern on Protein Turnover in Middle Age and Older Adults: A Randomized Controlled Trial.
J Nutr
December 2024
Department of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging & Longevity, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Background: Reduced meal frequency patterns have become popular for weight loss, maintenance, and improving cardiometabolic health. The extended fasting windows with these dietary patterns could lead to greater protein breakdown, which is a concern for middle-age and older adults who may need higher protein intakes to maintain or increase net protein balance.
Objective: The purpose of this study was to quantify muscle and whole-body protein kinetic responses to three different daily protein intakes within a two-meal eating pattern.
An aggressive Cushing's syndrome originating from a rare thymic neuroendocrine tumor, controlled successfully with fluconazole and octreotide therapy before surgery.
J Cancer Res Ther
August 2024
Department of Endocrinology, Akdeniz University Faculty of Medicine, Antalya, Turkey.
Article Synopsis
- - A 49-year-old woman experienced severe symptoms, including fatigue and resistant hypertension, leading to the diagnosis of ectopic Cushing's syndrome caused by an atypical neuroendocrine tumor found in the thymus.
- - Diagnostic tests confirmed excessive adrenocorticotropic hormone (ACTH) levels and indicated a tumor, which was surgically removed following successful medical management to lower cortisol levels.
- - Post-surgery, the patient entered clinical remission without tumor recurrence, demonstrating the importance of early detection and treatment of these rare and potentially life-threatening tumors.
The association of circulating systemic inflammation with premature death and the protective role of the Mediterranean diet: a large prospective cohort study of UK biobank.
BMC Public Health
May 2024
Department of Endocrinology and Metabolic Disease, the 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150081, China.
Background: Although previous studies have identified specific circulating inflammatory markers associated with the risk of mortality, they have often overlooked the broader impact of a comprehensive inflammatory response on health outcomes. This study aims to assess the association between circulating systemic inflammation and age-related hospitalization and premature death, as well as explore the potential mediating effects of various dietary patterns on these associations.
Methods: A total of 448,574 participants enrolled in the UK Biobank study were included.
Association of ultra-processed food consumption with muscle mass among young and middle-aged US adults.
Eur J Nutr
October 2024
Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Introduction: Muscle mass is vital for physical activity and fundamental physiological processes supporting long-term health. While aging is inevitable, certain modifiable factors positively influence muscle preservation and overall well-being. However, the relationship between the consumption of ultra-processed foods (UPF) and muscle mass is not yet clear.
View Article and Find Full Text PDFEvaluation of the safety, biodistribution, dosimetry of [F]AlF-NOTA-LM3 and head-to-head comparison with [Ga]Ga-DOTATATE in patients with well-differentiated neuroendocrine tumors: an interim analysis of a prospective trial.
Eur J Nucl Med Mol Imaging
October 2024
Department of Nuclear Medicine, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China.
Purpose: F-labelled somatostatin receptor (SSTR) analogs offer several advantages over Ga in terms of yield, cost, spatial resolution and detection rate. This study presents an interim analysis of a prospective trial designed to assess the safety, biodistribution and dosimetry of [F]AlF-NOTA-LM3, and compare its diagnostic efficacy and clinical management outcomes with [Ga]Ga-DOTATATE or [Ga]Ga-NODAGA-LM3 in patients with well-differentiated NETs.
Methods: Twenty-one patients with histologically confirmed well-differentiated neuroendocrine tumors (G1 and G2) were prospectively recruited.
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