Neuroimmunology of the female brain across the lifespan: Plasticity to psychopathology.

Brain Behav Immun

School of Health and Biomedical Sciences, RMIT University, Melbourne, Vic. 3083, Australia. Electronic address:

Published: July 2019

The female brain is highly dynamic and can fundamentally remodel throughout the normal ovarian cycle as well as in critical life stages including perinatal development, pregnancy and old-age. As such, females are particularly vulnerable to infections, psychological disorders, certain cancers, and cognitive impairments. We will present the latest evidence on the female brain; how it develops through the neonatal period; how it changes through the ovarian cycle in normal individuals; how it adapts to pregnancy and postpartum; how it responds to illness and disease, particularly cancer; and, finally, how it is shaped by old age. Throughout, we will highlight female vulnerability to and resilience against disease and dysfunction in the face of environmental challenges.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591071PMC
http://dx.doi.org/10.1016/j.bbi.2019.03.010DOI Listing

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