AI Article Synopsis
- Neuropathic pain is a tough type of pain that keeps coming back and doesn’t get better with regular treatments.
- Cannabinoids, which are substances found in cannabis plants, may help reduce this pain by working with the body's endocannabinoid system.
- A study found that certain cannabinoids effectively stopped a specific signaling pathway in the body that is related to pain, suggesting they could be useful in treating neuropathic pain.
Article Abstract
Neuropathic pain is a debilitating form of treatment-resistant chronic pain caused by damage to the nervous system. Cannabinoids have been known for suppressing neuropathic pain by modulating the endo cannabinoid system. Since the canonical Wnt/β-catenin signaling has recently been implicated in pain sensation, we investigated the impact of major cannabinoids (1-6) from the leaves of Cannabis sativa and an epoxy derivative of compound 2, here upon referred to as 2a, on modulating Wnt/β-catenin signaling pathway. The results presented in this study show that compound 1, 2 and 2a exhibited potent inhibitory activity against Wnt/β-catenin pathway in a dose-dependent manner. Compound 2a was seen to inhibit this pathway at slightly lower concentrations than its parent molecule 2, under similar conditions. Taken together, compound 1, 2 and 2a, by virtue of their inhibition of Wnt/β-catenin signaling pathway, could be developed as effective neuroprotective agents for the management of neuropathic pain.
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| http://dx.doi.org/10.1016/j.bmcl.2019.03.013 | DOI Listing |
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