Functionalisation of Silicone by Drug-Embedded Chitosan Nanoparticles for Potential Applications in Otorhinolaryngology.

Materials (Basel)

University Medical Centre Maribor, Department of Otorhinolaryngology, Cervical and Maxillofacial Surgery, Ljubljanska ulica 5, 2000 Maribor, Slovenia.

Published: March 2019

AI Article Synopsis

  • Silicones are utilized in medical applications, particularly tympanostomy tubes, with a goal to enhance healing for ear conditions through surface functionalization.
  • Various antimicrobial coatings, including chitosan nanoparticles and a drug mixture, were tested on silicone surfaces, with pre-treatment methods used to improve coating adhesion.
  • Results indicate that the functionalized silicone materials exhibit strong antimicrobial properties, demonstrating potential for improved treatment of ear inflammations and warranting further clinical testing.

Article Abstract

Silicones are widely used medical materials that are also applied for tympanostomy tubes with a trending goal to functionalise the surface of the latter to enhance the healing of ear inflammations and other ear diseases, where such medical care is required. This study focuses on silicone surface treatment with various antimicrobial coatings. Polysaccharide coatings in the form of chitosan nanoparticles alone, or with an embedded drug mixture composed of amoxicillin/clavulanic acid (co-amoxiclav) were prepared and applied onto silicone material. Plasma activation was also used as a pre-treatment for activation of the material's surface for better adhesion of the coatings. The size of the nanoparticles was measured using the DLS method (Dynamic Light Scattering), stability of the dispersion was determined with zeta potential measurements, whilst the physicochemical properties of functionalised silicone materials were examined using the UV-Vis method (Ultraviolet-Visible Spectroscopy), SEM (Scanning Electron Microscopy), XPS (X-Ray Photoelectron Spectroscopy). Moreover, in vitro drug release testing was used to follow the desorption kinetics and antimicrobial properties were tested by a bacterial cell count reduction assay using the standard gram-positive bacteria . The results show silicone materials as suitable materials for tympanostomy tubes, with the coating developed in this study showing excellent antimicrobial and biofilm inhibition properties. This implies a potential for better healing of ear inflammation, making the newly developed approach for the preparation of functionalised tympanostomy tubes promising for further testing towards clinical applications.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471903PMC
http://dx.doi.org/10.3390/ma12060847DOI Listing

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