Silicones are widely used medical materials that are also applied for tympanostomy tubes with a trending goal to functionalise the surface of the latter to enhance the healing of ear inflammations and other ear diseases, where such medical care is required. This study focuses on silicone surface treatment with various antimicrobial coatings. Polysaccharide coatings in the form of chitosan nanoparticles alone, or with an embedded drug mixture composed of amoxicillin/clavulanic acid (co-amoxiclav) were prepared and applied onto silicone material. Plasma activation was also used as a pre-treatment for activation of the material's surface for better adhesion of the coatings. The size of the nanoparticles was measured using the DLS method (Dynamic Light Scattering), stability of the dispersion was determined with zeta potential measurements, whilst the physicochemical properties of functionalised silicone materials were examined using the UV-Vis method (Ultraviolet-Visible Spectroscopy), SEM (Scanning Electron Microscopy), XPS (X-Ray Photoelectron Spectroscopy). Moreover, in vitro drug release testing was used to follow the desorption kinetics and antimicrobial properties were tested by a bacterial cell count reduction assay using the standard gram-positive bacteria . The results show silicone materials as suitable materials for tympanostomy tubes, with the coating developed in this study showing excellent antimicrobial and biofilm inhibition properties. This implies a potential for better healing of ear inflammation, making the newly developed approach for the preparation of functionalised tympanostomy tubes promising for further testing towards clinical applications.
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http://dx.doi.org/10.3390/ma12060847 | DOI Listing |
Eur Arch Otorhinolaryngol
December 2024
Departments of Otolaryngology-Head and Neck Surgery and Maxillofacial Surgery, School of Medicine, Tel Aviv Sourasky Medical Center, Tel-Aviv University, Tel Aviv, 6423907, Israel.
Objective: To characterize middle ear (ME) effusion still present 2 months after repair surgery for spontaneous cerebrospinal fluid (CSF) leak via the temporal bone (TB).
Study Design: A retrospective chart review (2011-2022).
Setting: Tertiary referral academic center.
Am J Otolaryngol
December 2024
Otorhinolaryngology Department, University of Navarra Clinic, Pamplona, Spain.
Introduction: Environmental changes and modifications in leisure habits have facilitated the emergence of new bacteria responsible for causing ear infections with different presentations. In this context, Turicella otitidis is a pathogen for which isolated cases of external and middle ear infections have been reported. However, our experience indicates a resurgence in its occurrence in recent years.
View Article and Find Full Text PDFEur Arch Otorhinolaryngol
December 2024
Department of Otolaryngology, Cohen Children's Medical Center, New Hyde Park, NY, USA.
Purpose: To compare the quality and readability of patient education materials on myringotomy tubes from artificial intelligence and Google search.
Methods: Three questions were posed to ChatGPT and Google Gemini addressing "Condition," "Investigation," and "Treatment" domains. Google was queried for "Ear tubes," "Myringotomy and tubes," and "Tympanostomy tubes.
Laryngoscope
December 2024
The Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A.
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