Parsimonious representations are ubiquitous in modeling and processing information. Motivated by the recent Multi-Layer Convolutional Sparse Coding (ML-CSC) model, we herein generalize the traditional Basis Pursuit problem to a multi-layer setting, introducing similar sparse enforcing penalties at different representation layers in a symbiotic relation between synthesis and analysis sparse priors. We explore different iterative methods to solve this new problem in practice, and we propose a new Multi-Layer Iterative Soft Thresholding Algorithm (ML-ISTA), as well as a fast version (ML-FISTA). We show that these nested first order algorithms converge, in the sense that the function value of near-fixed points can get arbitrarily close to the solution of the original problem. We further show how these algorithms effectively implement particular recurrent convolutional neural networks (CNNs) that generalize feed-forward ones without introducing any parameters. We present and analyze different architectures resulting from unfolding the iterations of the proposed pursuit algorithms, including a new Learned ML-ISTA, providing a principled way to construct deep recurrent CNNs. Unlike other similar constructions, these architectures unfold a global pursuit holistically for the entire network. We demonstrate the emerging constructions in a supervised learning setting, consistently improving the performance of classical CNNs while maintaining the number of parameters constant.
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CNS Neurosci Ther
December 2024
Department of Emergency Medicine, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Introduction: This review delves into the intricate relationship between NLR inflammasomes, particularly the NLRP3 inflammasome, and the immune-mediated neurodegenerative disease, multiple sclerosis (MS). While the precise etiology of MS remains elusive, compelling research underscores the pivotal role of the immune response in disease progression. Notably, recent investigations highlight the significant involvement of NLRP3 inflammasomes in various autoimmune diseases, prompting an in-depth exploration of their impact on MS.
View Article and Find Full Text PDFPeerJ Comput Sci
May 2024
Systems and Computing Engineering Department, Universidad de los Andes, Bogotá, Colombia.
Business process simulation is an established approach to estimate the potential impact of hypothetical changes on a process, particularly in terms of time and cost-related performance measures. To overcome the complexity associated with manually specifying and fine-tuning simulation models, data-driven simulation (DDS) methods enable users to discover accurate business process simulation models from event logs. However, in the pursuit of accuracy, DDS methods often generate overly complex models.
View Article and Find Full Text PDFPLoS One
December 2024
Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine & International Joint Research Center for Quality of Traditional Chinese Medicine & Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization, Hainan Branch of the Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haikou, China.
Adv Neurobiol
November 2024
Lurie Family Foundations MEG Imaging Center, Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
There is no simple blood test for autism. Consequently, much attention has been paid to identifying noninvasive biomarkers using imaging (e.g.
View Article and Find Full Text PDFTrends Pharmacol Sci
December 2024
Division of Infectious Diseases, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA; Penn Institute for RNA Innovation, University of Pennsylvania, Philadelphia, PA, USA; Infectious Diseases Section, Department of Medicine, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, USA. Electronic address:
The unprecedented global spread of monkeypox (mpox) has reinvigorated the pursuit of next-generation poxvirus vaccines. Given the success of the mRNA-lipid nanoparticle (LNP) vaccine platform to vaccinate against SARS-CoV-2, candidate poxvirus mRNA vaccines, as recently reported by Zuiani et al. and Mucker et al.
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