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G3BP2 promotes tumor progression and gemcitabine resistance in PDAC via regulating PDIA3-DKC1-hENT in a stress granules-dependent manner.
Acta Pharmacol Sin
September 2024
Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with limited treatment options and a tendency to resist chemotherapy, emphasizing the need for new research in therapies.
- The study focuses on G3BP2, a key component of stress granules (SGs) that is linked to cancer progression and chemotherapy resistance, revealing its elevated expression in PDAC is associated with poorer patient survival.
- The researchers found that G3BP2 promotes PDAC chemotherapy resistance by stabilizing the mRNA of DKC1, which subsequently inhibits the expression of hENT, thereby suggesting that targeting G3BP2 could be a potential therapeutic strategy for PDAC.
ZCCHC8 p.P410A disrupts nucleocytoplasmic localization, promoting idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.
Mol Med
September 2024
Department of Pulmonary and Critical Care Medicine, Research Unit of Respiratory Disease, Hunan Diagnosis and Treatment Center of Respiratory Disease, the Second Xiangya Hospital, Central South University, Changsha, 410011, China.
Background: Idiopathic pulmonary fibrosis (IPF) is a special kind of chronic interstitial lung disease with insidious onset. Previous studies have revealed that mutations in ZCCHC8 may lead to IPF. The aim of this study is to explore the ZCCHC8 mutations in Chinese IPF patients.
View Article and Find Full Text PDFcharacterization and identification of compound heterozygous variants in H/ACA Ribonucleoprotein Assembly Factor () from Indian population.
J Family Med Prim Care
January 2024
Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.
Background: H/ACA small nucleolar ribonucleoproteins (snoRNP) form a complex with multiple proteins to accomplish the pseudouridylation of rRNA. The assembly of H/ACA small nucleolar ribonucleoproteins (snoRNP) is initiated by H/ACA ribonucleoprotein Assembly factor, that is, SHQ1. Mutations in have been reported to cause two disorders namely, dystonia-35 childhood onset (OMIM*619921) and neurodevelopmental disorder with seizures and dystonia (OMIM*619922), both of which are inherited in an autosomal recessive manner.
View Article and Find Full Text PDFBackground: High-grade bladder cancer (HGBC) has a higher malignant potential, recurrence and progression rate compared to low-grade phenotype. Its early symptoms are often vague, making non-invasive diagnosis using urinary biomarkers a promising approach.
Methods: The gene expression data from urine samples of patients with HGBC was extracted from the GSE68020 dataset.
AC125611.3 promotes the progression of colon cancer by recruiting DKC1 to stabilize CTNNB1.
Arab J Gastroenterol
August 2023
School of Basic Medicine, Youjiang Medical University for Nationalities, No. 98 Chengxiang Road, Youjiang District, Baise 533000, Guangxi, China.
Background And Study Aims: Previous studies have suggested that lncRNAs impact cancer progression. The lncRNA AC125611.3 (also referred to as RP11-161H23.
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