AI Article Synopsis
- The study focuses on the immune mechanisms behind treatment-free remission (TFR) in chronic myeloid leukemia (CML), highlighting the lack of defined correlations with CD8(+) T-cell types.
- Researchers identified a new subset of CD8(+) T-cells called innate CD8(+) T-cells in CML patients who enjoyed TFR for over two years, showing a significant increase in their functionality compared to control and treated patients.
- The findings suggest a positive relationship between the levels of innate CD8(+) T-cells and natural killer cells, indicating a potential new biomarker profile for successful TFR in CML patients.
Article Abstract
Immunological mechanisms of treatment-free remission (TFR) in chronic myeloid leukaemia (CML) are poorly defined and, to date, no correlation between successful TFR and CD8(+) T-cell subsets has been found. We analysed a new identified human subset of CD8(+) T-cells, namely innate CD8(+) T-cells, in CML patients with TFR ≥ 2 years. We demonstrated a dramatic increase of functionally active innate CD8(+) T-cells in these patients as compared to control subjects and patients in remission under tyrosine kinase inhibitors. Moreover, we found a positive correlation between frequencies of innate CD8(+) T-cells and natural killer cells, possibly representing a new innate biomarker profile of successful TFR.
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| http://dx.doi.org/10.1111/bjh.15858 | DOI Listing |
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