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A biodegradable magnesium alloy promotes subperiosteal osteogenesis via interleukin-10-dependent macrophage immunomodulation.
Biomaterials
December 2024
Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, China; Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, Beijing, China. Electronic address:
In situ bone regeneration and vertical bone augmentation have been huge problems in clinical practice, always imposing a significant economic burden and causing patient suffering. Herein, MgZnYNd magnesium alloy rod implantation in mouse femur resulted in substantial subperiosteal new bone formation, with osteoimmunomodulation playing a pivotal role. Abundant macrophages were attracted to the subperiosteal new bone region and proved to be the most important regulation cells for bone regeneration.
View Article and Find Full Text PDFEvaluation of Prediction Models for the Capping and Breaking Force of Tablets Using Machine Learning Tools in Wet Granulation Commercial-Scale Pharmaceutical Manufacturing.
Pharmaceuticals (Basel)
December 2024
College of Pharmacy, Dankook University, 119, Dandae-ro, Dongnam-gu, Cheonan-si 31116, Republic of Korea.
: This study aimed to establish a predictive model for critical quality attributes (CQAs) related to tablet integrity, including tablet breaking force (TBF), friability, and capping occurrence, using machine learning-based models and nondestructive experimental data. : The machine learning-based models were trained on data to predict the CQAs of metformin HCl (MF)-containing tablets using a commercial-scale wet granulation process, and five models were each compared for regression and classification. We identified eight input variables associated with the process and material parameters that control the tableting outcome using feature importance analysis.
View Article and Find Full Text PDFMicrostructure and Mechanical Properties of Mg-8Li-3Al-0.3Si Alloy Deformed Through a Combination of Back-Extrusion and Spinning Process.
Materials (Basel)
January 2025
Shanxi Key Laboratory of Magnesium-Based Materials, College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, China.
In this work, the Mg-8Li-3Al-0.3Si (LAS830) alloy was prepared by the vacuum melting method. The as-cast alloy was subjected to backward extrusion at 250 °C and then spun at 250 °C.
View Article and Find Full Text PDFCrystal and Dislocation Characteristics of Ti-6Al-4V Alloy Under Effect of Laser Shock Peening.
Materials (Basel)
January 2025
College of Materials Science and Engineering, Chongqing University, Chongqing 400045, China.
Laser shock peening (LSP) is an effective method for enhancing the fatigue life and mechanical properties of Ti alloys. However, there is limited research on the effects of LSP on crystal structure and dislocation characteristics. In this study, Ti-6Al-4V alloy was subjected to laser shock peening with varying laser power levels.
View Article and Find Full Text PDFMicrostructure and Mechanical Properties of High-Pressure Die-Casting Mg-Al-RE Alloys with Minor Ca Addition.
Materials (Basel)
January 2025
Key Laboratory of Automobile Materials, Ministry of Education, School of Materials Science and Engineering, Jilin University, 5988# Renmin Street, Changchun 130025, China.
With the increasing demand for magnesium (Mg) alloys with high strength and good ductility, this study explores high-pressure die-cast (HPDC) Mg-6Al-2RE (AE62), Mg-8Al-2RE (AE82) and Mg-8Al-2RE-0.2Ca (AEX820) alloys (wt. %).
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