AI Article Synopsis
- * The synthesis method involved sequentially building the pentasaccharide from a common disaccharide and adding a rare sugar unit at the end.
- * The final product was created as a 2-aminoethyl glycoside, which is important for creating glyconjugates, using stereoselective glycosylations activated by specific reagents.
Article Abstract
Chemical synthesis of the pentasaccharide repeating unit of the O-specific polysaccharide from Aeromonas hydrophilastrain K691 is reported. Synthesis of the pentasaccharide is accomplished by using a common disaccharide in sequence and finally attaching the rare sugar unit. The target structure was made in the form of its 2-aminoethyl glycoside which is essential for further glycconjugate formation. Stereoselective glycosylations were achieved by the activation of thioglycosides in the presence of HSO-silica in conjunction with N-iodosuccinimide.
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| http://dx.doi.org/10.1016/j.carres.2019.02.009 | DOI Listing |
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