AI Article Synopsis
- Myelin is not just formed during early development; it can also be generated in adulthood, suggesting the brain maintains the ability to adapt and change throughout life.
- The highest cognitive functioning areas of the human brain may take decades to fully myelinate, indicating a prolonged developmental process.
- There is a lack of understanding regarding the impact and regulation of myelination in grey matter, which raises important questions about its role in brain function and potential impact on neurological and psychiatric disorders.
Article Abstract
There is now increasing evidence that myelin is not only generated early in development, but also during adulthood possibly contributing to lifelong plasticity of the brain. In particular, human cortical areas responsible for the highest cognitive functions seem to require decades until they have reached their maximal amount of myelination. Currently, we know very little about the mechanisms and the functions of grey matter myelination. In this emerging field key questions await to be addressed: How long does myelination last in humans? How is grey matter myelination regulated? What is the function of myelin in the grey matter? Does grey matter myelination limit and/or promote neuronal plasticity? Finding answers to these questions will be important for our understanding of normal, but also abnormal cortex function in a number of neurological and psychiatric diseases.
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| http://dx.doi.org/10.1002/glia.23614 | DOI Listing |
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