This study proposes a highly sensitive refractive-index (RI) sensor based on a TM₀ waveguide mode resonance excited in an asymmetric metal-cladding dielectric waveguide structure, where the analyte serves as the guiding layer. By scanning the wavelength at fixed angles of incidence, the reflection spectra of the sensor were obtained. The results showed that the resonance wavelength redshifted dramatically with increases in the analyte RI, which indicates that this approach can be used to sense both the resonance wavelength and the analyte RI. Based on this approach, we investigated the sensing properties, including the sensitivity and figure of merit, at fixed incident angles of 60° and 45°, at which the sensitivity of the sensor reached 7724.9 nm/RIU (refractive index units) and 1339 nm/RIU, respectively. Compared with surface plasmon resonance sensors, which are based on a similar structure, the proposed sensor can accept a more flexible range of incident angles and a wider sensing range of analyte RI. This approach thus has tremendous potential for use in numerous sensing domains, such as biochemical and medical analyses.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427475PMC
http://dx.doi.org/10.3390/s19051187DOI Listing

Publication Analysis

Top Keywords

highly sensitive
8
sensitive refractive-index
8
refractive-index sensor
8
sensor based
8
based tm₀
8
tm₀ waveguide
8
waveguide mode
8
mode resonance
8
resonance excited
8
excited asymmetric
8

Similar Publications

This study proposes a novel, highly sensitive neutron detector design utilizing a unique multi-layered configuration. Each layer consists of a LiF: ZnS(Ag) scintillator coupled with a transparent neutron moderator that also functions as a light guide for the Silicon Photomultiplier (SiPM) light sensor. This design offers a cost-effective and readily available alternative for existing neutron detectors.

View Article and Find Full Text PDF

This paper presents a slot antenna integrated with a split ring resonator (SRR) and feed line, designed to achieve a high Q-factor while maximizing channel capacity utilization. By incorporating a lens into the dielectric resonator antenna (DRA), we enhance both bandwidth and directivity, with the dielectric material's permittivity serving as a key control parameter for radiation characteristics. We explore water and ethanol as controllable dielectrics within the terahertz (THz) frequency range (0.

View Article and Find Full Text PDF

We report the development and performance of a novel genomics platform, TempO-LINC, for conducting high-throughput transcriptomic analysis on single cells and nuclei. TempO-LINC works by adding cell-identifying molecular barcodes onto highly selective and high-sensitivity gene expression probes within fixed cells, without having to first generate cDNA. Using an instrument-free combinatorial indexing approach, all probes within the same fixed cell receive an identical barcode, enabling the reconstruction of single-cell gene expression profiles across as few as several hundred cells and up to 100,000 + cells per sample.

View Article and Find Full Text PDF

The cyclic GMP-AMP synthase-stimulator of the interferon gene (cGAS-STING) signaling pathway is considered an essential pattern recognition and effector pathway in the natural immune system and is mainly responsible for recognizing DNA molecules present in the cytoplasm and activating downstream signaling pathways to generate type I interferons (IFN-I) and other inflammatory factors. STING, a crucial junction protein in the innate immune system, exerts an essential role in host resistance to external pathogen invasion. The DNA introduced by pathogens or tumors is recognized by the cytoplasmic nucleic acid receptor cGAS, and a second messenger, cGAMP, is generated using intracellular guanosine triphosphate (GTP) and adenosine triphosphate (ATP).

View Article and Find Full Text PDF

The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients.

Sci Rep

December 2024

Institute of Dermatology, Peking Union Medical College, Chinese Academy of Medical Sciences, National Center for STD Control, Centers for Disease Control and Prevention, Nanjing, China.

Diagnosing neurosyphilis in clinical settings poses significant challenges due to the absence of highly efficient diagnostic criteria. Our objective was to enhance the existing diagnostic criteria and assess their sensitivity and specificity for identifying neurosyphilis in HIV-negative patients. We conducted a retrospective review of patient records from a cross-sectional study carried out between December 2019 and May 2023.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!