This study proposes a highly sensitive refractive-index (RI) sensor based on a TM₀ waveguide mode resonance excited in an asymmetric metal-cladding dielectric waveguide structure, where the analyte serves as the guiding layer. By scanning the wavelength at fixed angles of incidence, the reflection spectra of the sensor were obtained. The results showed that the resonance wavelength redshifted dramatically with increases in the analyte RI, which indicates that this approach can be used to sense both the resonance wavelength and the analyte RI. Based on this approach, we investigated the sensing properties, including the sensitivity and figure of merit, at fixed incident angles of 60° and 45°, at which the sensitivity of the sensor reached 7724.9 nm/RIU (refractive index units) and 1339 nm/RIU, respectively. Compared with surface plasmon resonance sensors, which are based on a similar structure, the proposed sensor can accept a more flexible range of incident angles and a wider sensing range of analyte RI. This approach thus has tremendous potential for use in numerous sensing domains, such as biochemical and medical analyses.
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http://dx.doi.org/10.3390/s19051187 | DOI Listing |
J Transl Med
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Department of Pathology, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe East Road, Zhengzhou, China.
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Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Creating fast, non-invasive, precise, and specific diagnostic tests is crucial for enhancing cancer treatment outcomes. Among diagnostic methods, those relying on nucleic acid detection are highly sensitive and specific. Recent developments in diagnostic technologies, particularly those leveraging Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR), are revolutionizing cancer detection, providing accurate and timely results.
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Powell Mansfield, Inc., San Diego, CA, USA.
Obstructive sleep apnea (OSA) is widespread, under-recognized, and under-treated, impacting the health and quality of life for millions. The current gold standard for sleep apnea testing is based on the in-lab sleep study, which is costly, cumbersome, not readily available and represents a well-known roadblock to managing this huge societal burden. Assessment of neuromuscular function involved in the upper airway using electromyography (EMG) has shown potential to characterize and diagnose sleep apnea, while the development of transmembranous electromyography (tmEMG), a painless surface probe, has made this opportunity practical and highly feasible.
View Article and Find Full Text PDFLight Sci Appl
January 2025
School of Physics, University of the Witwatersrand, Private Bag 3, Johannesburg, 2050, South Africa.
Optical metrology is a well-established subject, dating back to early interferometry techniques utilizing light's linear momentum through fringes. In recent years, significant interest has arisen in using vortex light with orbital angular momentum (OAM), where the phase twists around a singular vortex in space or time. This has expanded metrology's boundaries to encompass highly sensitive chiral interactions between light and matter, three-dimensional motion detection via linear and rotational Doppler effects, and modal approaches surpassing the resolution limit for improved profiling and quantification.
View Article and Find Full Text PDFAnticancer Res
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Proton Medical Research Center, University of Tsukuba, Ibaraki, Japan.
Background/aim: This study aimed to predict the optimal timing for adaptive radiation therapy (ART) using two-dimensional X-ray image-based water equivalent thickness (2DWET).
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