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Recent advances in the synthesis of gem-dimethylcyclobutane natural products. | LitMetric

Recent advances in the synthesis of gem-dimethylcyclobutane natural products.

Nat Prod Rep

Department of Chemistry, Indiana University, 800 E. Kirkwood Ave., Bloomington, IN 47405, USA.

Published: October 2019

AI Article Synopsis

Article Abstract

Covering: January 2000 to July 2018 gem-Dimethylcyclobutanes are a common motif found in a multitude of natural products, and thus these structures have captivated synthetic chemists for years. However, until the turn of the century, most synthetic efforts relied upon the use of widely available terpenes, such as pinene or caryophyllene, that already contain the gem-dimethylcyclobutane motif. This approach limits the scope of molecules that can be accessed readily. This review highlights recent syntheses in which the gem-dimethylcyclobutane is assembled via de novo approaches. An outlook on the future of this research area is also provided.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739199PMC
http://dx.doi.org/10.1039/c8np00083bDOI Listing

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