Background And Purpose: Caffeine is ubiquitous in foods, supplements, and medications and has been hypothesized to be associated with several health-related outcomes, including mental health disorders such as anxiety. We explored a possible relationship between caffeine consumption and depression using data from the National Health and Nutrition Examination Survey (NHANES).
Methods: Data from 1,342 adult NHANES participants were included. Statistical software for complex survey sample designs was used to perform two multivariable logistic regressions with a binary indicator of depression as the dependent variable: one using dietary caffeine consumption and one using the caffeine metabolite AAMU as the independent variable. Both analyses were adjusted for gender, race/ethnicity, smoking status, and use of anti-depressants.
Results: We observed a descriptive, albeit non-significant ( = 0.12), pattern of increasing odds of depression with increasing levels of the AAMU caffeine metabolite.
Conclusion: Our finding of a possible association between caffeine metabolite level and depression is compelling because it is independent of self-reported caffeine consumption. Prospective studies are warranted to further explore the temporal relationship.
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Alzheimers Dement
December 2024
School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Background: The role of coffee and tea intake in dementia prevention remains inconclusive across studies.
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Pediatr Allergy Immunol
January 2025
EPIUnit-Institute of Public Health, University of Porto, Porto, Portugal.
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Food Chem Toxicol
January 2025
Military Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, MA, USA. Electronic address:
Caffeine is a popular stimulant, predominantly consumed from beverages. The caffeinated beverage marketplace is continually evolving resulting in considerable interest in understanding the impact caffeinated beverages have on levels of intakes. Therefore, estimates of caffeine intakes in the U.
View Article and Find Full Text PDFNutrients
December 2024
Laboratory of Genetics of Aging and Longevity, Kazan State Medical University, 420012 Kazan, Russia.
Background: The monocarboxylate transporter 1 (MCT1) plays a crucial role in regulating lactate and pyruvate transport across cell membranes, which is essential for energy metabolism during exercise. The A1470T (rs1049434) polymorphism has been suggested to influence lactate transport, with the T (major) allele associated with greater transport efficiency. This study aimed to investigate the effect of the polymorphism on lactate and potassium (K) concentrations in response to resistance exercise (RE) following caffeine (CAF) ingestion.
View Article and Find Full Text PDFNutrients
December 2024
Department of Pathobiochemistry and Interdisciplinary Applications of Ion Chromatography, Medical University of Lublin, 1 Chodźki St., 20-093 Lublin, Poland.
In recent years, the consumption of energy drinks (EDs) by adolescents and young adults has increased significantly, so concerns have been raised about the potential health risks associated with excessive ED consumption. Most analyses on EDs focus on the caffeine content. Research on the content of minerals (essential and toxic) in energy drinks can be considered scarce.
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