Background And Objectives: Intolerance of uncertainty (IU), or fear of the unknown, is as an important transdiagnostic risk factor across anxiety-related conditions, namely generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD), and social anxiety disorder (SAD). IU is typically indexed using self-report measures. Given the importance of multi-method assessments and the shortcomings associated with existing behavioral indices of IU, additional methods of assessment are needed. Emerging literature supports the use of interpretation bias (IB) paradigms to index constructs such as IU. However, only one study to date has examined the association between an IU-focused IB paradigm (IU-IB) and self-report IU and no research has investigated whether an IU-IB paradigm would be related to increased anxiety-related symptoms.
Methods: The current investigation examined the utility of an IU-IB paradigm across two separate samples wherein participants completed an interpretation bias task and self-report measures. Sample 1 included 86 participants (74.4% female; Mage = 19.14) and sample 2 included 138 participants (79.7% female; Mage = 18.88).
Results: Findings from Study 1 indicated a significant association between an exaggerated IU-IB and symptoms of GAD and OCD, and this relationship held after covarying for negative affect. Study 2 results indicated a significant relationship between an exaggerated IU-IB and symptoms of GAD, OCD, and SAD, after covarying for negative affect.
Limitations: The current study had a variety of limitations, including the use of cross-sectional data and an undergraduate sample.
Conclusions: These findings provide an important replication and extension of previous work and highlight the transdiagnostic utility of this IU-IB task.
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http://dx.doi.org/10.1016/j.jbtep.2019.02.010 | DOI Listing |
HGG Adv
January 2025
Insitro, South San Francisco, CA, USA.
Genome-wide association studies (GWAS) are often performed on ratios composed of a numerator trait divided by a denominator trait. Examples include body mass index (BMI) and the waist-to-hip ratio, among many others. Explicitly or implicitly, the goal of forming the ratio is typically to adjust for an association between the numerator and denominator.
View Article and Find Full Text PDFEpilepsia
January 2025
Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
Objective: Temporal encephaloceles (TEs) are seen in patients with drug-resistant epilepsy (DRE); yet they are also common incidental findings. Variability in institutional pre-surgical epilepsy practices and interpretation of epileptogenic network localization contributes to bias in existing epilepsy cohorts with TE, and therefore the relevance of TE in DRE remains controversial. We sought to estimate effect sizes and sample sizes necessary to demonstrate clinically relevant improvements in seizure outcome with different surgical approaches.
View Article and Find Full Text PDFAnn Transl Med
December 2024
Division of Advanced Gastrointestinal and Bariatric Surgery, Mayo Clinic, Jacksonville, FL, USA.
Background: Addressing language barriers through accurate interpretation is crucial for providing quality care and establishing trust. While the ability of artificial intelligence (AI) to translate medical documentation has been studied, its role for patient-provider communication is less explored. This review evaluates AI's effectiveness in clinical translation by assessing accuracy, usability, satisfaction, and feedback on its use.
View Article and Find Full Text PDFJ Toxicol Environ Health A
January 2025
Department of Clinical, Forensic, Environmental, and Industrial Toxicology, University Hospital of Liege, Liege, Belgium.
Designing ideal human biomonitoring studies involves the selection of reliable markers of exposure in adequate biological matrix. Besides conventional matrices such as blood or urine, hair has been increasingly investigated as a promising noninvasive alternative. However, understanding the pollutant distribution between differing biological compartments is essential for reliable interpretation of data collected.
View Article and Find Full Text PDFAm J Biol Anthropol
January 2025
Michale E. Keeling Center for Comparative Medicine and Research, University of Texas MD Anderson Cancer Center, Bastrop, Texas, USA.
Objectives: Most human brains exhibit left hemisphere asymmetry for planum temporale (PT) surface area and gray matter volume, which is interpreted as cerebral lateralization for language. Once considered a uniquely human feature, PT asymmetries have now been documented in chimpanzees and olive baboons. The goal of the current study was to further investigate the evolution of PT asymmetries in nonhuman primates.
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