We describe a case report of a 56-year-old male with undiagnosed multiple myeloma who had severe sepsis associated with pneumonia, meningitis, polyarthritis, and osteomyelitis related to invasive "Haemophilus quentini" infection. The genus was misidentified as H. influenzae by the common bacterial identification systems including newly introduced syndromic PCR-based methods. We review the epidemiological, clinical, and laboratory aspects of this rare, cryptic species of Haemophilus.
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http://dx.doi.org/10.1016/j.diagmicrobio.2019.02.004 | DOI Listing |
J Clin Microbiol
December 2019
Public Health Agency of Canada, National Microbiology Laboratory, Winnipeg, Manitoba, Canada.
is a well-established human pathogen capable of causing a range of respiratory and invasive diseases. Since the 1970s, it has been observed that a nontypeable cryptic genospecies of , most often biotype IV, has been associated with the genitourinary tracts of females and with invasive neonatal infections. This distinct genospecies has been provisionally named "" Here, we report seven cases of invasive disease in patients from Ontario, Canada, over a 2-year period.
View Article and Find Full Text PDFDiagn Microbiol Infect Dis
July 2019
Central Laboratories, Ministry of Health, Jerusalem, Israel.
We describe a case report of a 56-year-old male with undiagnosed multiple myeloma who had severe sepsis associated with pneumonia, meningitis, polyarthritis, and osteomyelitis related to invasive "Haemophilus quentini" infection. The genus was misidentified as H. influenzae by the common bacterial identification systems including newly introduced syndromic PCR-based methods.
View Article and Find Full Text PDFGenome
May 2018
a Micropathology Ltd., University of Warwick Science Park, Coventry, United Kingdom.
Comparison of the genome of the Gram negative human pathogen Haemophilus quentini MP1 with other species of Haemophilus revealed that, although it is more closely related to Haemophilus haemolyticus than Haemophilus influenzae, the pathogen is in fact genetically distinct, a finding confirmed by phylogenetic analysis using the H. influenzae multilocus sequence typing genes. Further comparison with two other H.
View Article and Find Full Text PDFJ Infect Chemother
January 2018
Department of Urology, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Gifu 501-1194, Japan. Electronic address:
We isolated a cryptic genospecies of Haemophilus influenzae referred to as 'Haemophilus quentini' in the urethra of 3 men complaining of urethritis symptoms. H. influenzae strains, which had been isolated from the urethra in 77 of 1518 men complaining of urethritis symptoms, identified by the conventional test, and stored, were re-cultured for this study.
View Article and Find Full Text PDFGenome Announc
November 2016
Department of Clinical Laboratory and Microbiology Sciences, Public Health Laboratories, Public Health Ontario, Toronto, Ontario, Canada
Here, we present the draft genome sequences of two strains (K068 and C860) of the genospecies "Haemophilus quentini" The isolates were recovered from blood cultures of a newborn neonate and an elderly patient with septicemia in Ontario, Canada.
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