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Novel functions of o-cymen-5-ol nanoemulsion in reversing colistin resistance in multidrug-resistant Klebsiella pneumoniae infections.
Biochem Pharmacol
September 2024
Department of Food Science, College of Food Science and Engineering, Jilin University, Changchun 130062, China; State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China. Electronic address:
Multidrug resistance (MDR) Klebsiella pneumoniae (K. pneumoniae) is a major emerging threat to human health, and leads to very high mortality rate. The effectiveness of colistin, the last resort against MDR Gram-negative bacteria, is significantly compromised due to the widespread presence of plasmid- or chromosome-mediated resistance genes.
View Article and Find Full Text PDFRole of the ISKpn element in mediating mgrB gene mutations in ST11 hypervirulent colistin-resistant .
Front Microbiol
September 2023
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Nanchang University, Nanchang University, Nanchang, China.
Background: Colistin has emerged as a last-resort therapeutic against antibiotic-resistant bacterial infections, particularly those attributed to carbapenem-resistant Enterobacteriaceae (CRE) like CRKP. Yet, alarmingly, approximately 45% of multidrug-resistant strains now manifest resistance to colistin. Through our study, we discerned that the synergy between carbapenemase and IS elements amplifies resistance in , thereby narrowing the existing therapeutic avenues.
View Article and Find Full Text PDFGenetic characteristic of coexisting of and in isolates from lesion-bearing animal organs.
Front Microbiol
March 2023
Henan Institute of Modern Chinese Veterinary Medicine, Zhengzhou, Henan, China.
The coexistence of and in the plasmid of has been widely reported and such strains have been mainly isolated from animal and human feces. However, few reports have focused on the genetic diversity of -carrying chromosomes and -carrying plasmids in isolates from lesion-bearing animal organs. This study investigated the genetic characteristics of chromosome-mediated and plasmid-mediated in isolated from lesion-bearing animal organs.
View Article and Find Full Text PDF-Mediated In Vitro Inhibition of Plasmid Transfer Is Reversed by the Intestinal Environment.
Antibiotics (Basel)
June 2022
Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, 210095 Nanjing, China.
Colistin is regarded as an antibiotic of last resort against multidrug-resistant Gram-negative bacteria, including and . Colistin resistance is acquired by microorganisms via chromosome-mediated mutations or plasmid-mediated mobile colistin resistance () gene, in which the transfer of is the predominant factor underlying the spread of colistin resistance. However, the factors that are responsible for the spread of the gene are still unclear.
View Article and Find Full Text PDFGenetic Features of Plasmid- and Chromosome-Mediated in Isolates From Animal Organs With Lesions.
Front Microbiol
August 2021
College of Veterinary Medicine, Northwest A&F University, Yangling, China.
The genomic context of the gene in from animal feces has been widely reported. However, less is known about the -carrying plasmid characteristics and other functional regions of isolates from animal organs with lesions. The present study investigated the antimicrobial resistance, population structure, and genetic features of -positive strains isolated from animal organs with lesions.
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