Spindle cell/pleomorphic lipomas are benign lipomatous neoplasms that show loss of RB1 and classically harbor components of mature adipose tissue, bland spindled cells and ropy collagen. This review highlights the clinicopathologic features and morphologic spectrum of spindle cell/pleomorphic lipoma, discusses an updated differential diagnosis, and provides a practical diagnostic strategy for spindle cell/pleomorphic lipomas with atypical clinical presentations.
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| http://dx.doi.org/10.1053/j.semdp.2019.02.005 | DOI Listing |
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Atypical Spindle Cell/Pleomorphic Lipomatous Tumor With Hibernoma-Like Morphology: Expanding the Morphological Spectrum.
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Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium.
Lipomatous Neoplasms of Soft Tissue: A Contemporary Review.
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This review summarizes the clinicopathologic features of various lipomatous tumors of soft tissue and addresses some recent conceptual issues relating to adipocytic neoplasms, such as atypical spindle cell/pleomorphic lipomatous tumor and myxoid pleomorphic liposarcoma, and provides an update on the molecular aspects of these tumors. Recent advances in cytogenetic characterization and classification of lipomatous tumors are reviewed, and the genetic importance of distinct chromosomal aberrations are briefly discussed.
View Article and Find Full Text PDFAtypical Spindle Cell/Pleomorphic Lipomatous Tumor: A Review and Update.
Cancers (Basel)
September 2024
Department of Pathology, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
Article Synopsis
- Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare fat tumor that usually appears in the skin layer of middle-aged adults' limbs, potentially returning after incomplete removal but not spreading to distant areas.
- Histologically resembling spindle cell/pleomorphic lipoma, ASCPLT shows a mix of abnormal cells, including atypical spindle cells and multinucleated giant cells, and can sometimes undergo a change to a more aggressive form, although its significance is still unclear.
- The primary treatment is complete surgical removal, and the review covers the tumor's clinical features, pathology, and ongoing discussions about differentiating it from similar tumors.
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- - The most common types of liposarcomas are well-differentiated and dedifferentiated liposarcomas, usually found in the deep retroperitoneum or extremities, while atypical lipomatous tumors (ALT) are rare and less studied when located superficially.
- - A case study of a 54-year-old man revealed an ALT on his left upper back that had unusual characteristics, including significant pleomorphism and specific gene amplifications, which sets it apart from typical ALT cases reported.
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- Atypical spindle cell/pleomorphic lipomatous tumor is generally classified as a benign tumor, but can be confusing to diagnose due to varying MRI findings.
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- The final diagnosis was confirmed through detailed histopathology techniques, highlighting the importance of tissue analysis over imaging alone for accurate diagnosis.
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