Five new phloroglucinol derivatives, eucalyptins C-G (1-5), together with 13 known analogues (6-18) were isolated from the fruits of Eucalyptus globulus. The structures and absolute configurations of 1-5 were established by means of spectroscopic data analysis, computational calculation methods, and single-crystal X-ray diffraction. Compounds 1-18 were investigated for their immunosuppressive effects in vitro, and 1, 2, 6, and 7 displayed moderate inhibitory activities with IC values of 11.8, 10.2, 18.2, and 19.1 μM, respectively. The stimulation index (SI) of 1 was 64.2 and was compared to that of cyclosporine A (SI = 149.57). Further study demonstrated that 1 exhibited an immunosuppressive effect through inducing apoptosis and inhibiting cytokine secretion.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/acs.jnatprod.8b00920 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sawdust-based compost for production of Pycnoporus sanguineus basidiocarps.
Arch Microbiol
December 2024
Department of Agronomy, Universidade Estadual Do Oeste Do Paraná, Marechal Cândido Rondon, PR, Brazil.
This work aimed to get compost with cellulose-rich residues for Pycnoporus sanguineus basidiocarp production. Two isolates of P. sanguineus (Ps08 and Ps14) were grown in polypropylene bags containing sawdust of Eucalyptus sp.
View Article and Find Full Text PDFMixing oak and eucalyptus sawdusts improves shiitake (Lentinula edodes) yield and nutritional value.
PLoS One
November 2024
Department of Plant Production, Faculty of Agriculture, Lebanese University, Beirut, Lebanon.
The study aimed to explore suitable substrates comprising locally available hardwood sawdusts for the cultivation of Shiitake (Lentinula edodes) in Lebanon. Sawdusts of oak (OS), maple (MAP), and eucalyptus (EUC) were used alone or in combination, supplemented equally by wheat bran (WB). Results showed that complete mycelia run, fruiting, and harvest dates were the minimum in OS-WB: 800-200 by 72.
View Article and Find Full Text PDFDefinition of reproductive structures in Eucalyptus for phenological data collection.
Int J Biometeorol
November 2024
School of Agriculture, Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Burnley, Victoria, 3121, Australia.
In an era where global climate change is shifting plant phenology, global meta-analyses of multiple species are required more than ever. Common language or references for enhanced data compatibility are key for such analyses. Although the Plant Phenology Ontology (PPO) addresses this challenge, it does not capture several relevant reproductive structures that are critical in species with long reproductive cycles, like many Eucalyptus species.
View Article and Find Full Text PDFDetermination of insecticidal potential of selected plant extracts against fall armyworm () larvae.
Heliyon
October 2024
Entomological Research Institute, Ayub Agricultural Research Institute, Faisalabad, Punjab, Pakistan.
Article Synopsis
- The fall armyworm is a serious agricultural pest that harms various crops, prompting a study on the effectiveness of native plant extracts as natural insecticides.
- Different concentrations of ethanolic plant extracts were tested on third-instar larvae, revealing significant mortality rates, especially at the highest concentration (400 ppm) compared to a standard chemical insecticide, Spinetoram.
- Analysis showed the plant extracts contained biologically active compounds, suggesting they could serve as eco-friendly alternatives for pest control, benefiting both the economy and the environment.
Deciphering Hyperammonia-Producing Bacteria (HAB) in the Rumen of Water Buffaloes () and Their Inhibition through Plant Extracts and Essential Oils.
Microorganisms
October 2024
Division of Animal Physiology & Reproduction, ICAR-Central Institute for Research on Buffaloes, Hisar 125001, Haryana, India.
Hyperammonia-producing bacteria (HAB) are a class of microbes present in the stomach of ruminants, responsible for the rapid rate of ammonia production from protein degradation beyond the capacity of these animals for their utilization. Thus, ruminant nutritionists are interested in decreasing ruminal protein degradation and ammonia genesis by focusing on controlling the activity of HAB. The investigations of the present study were carried out to determine predominant hyperammonia-producing bacteria in the rumen of buffaloes, their isolation and characterization, as well as the inhibition of these isolates with various sources of plant secondary compounds (tannins, saponins, and essential oils).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!