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Local and systemic biodistribution of a small-molecule radiopharmaceutical probe after transcatheter embolization and intra-arterial delivery in a porcine orthotopic renal tumor model.
Nucl Med Commun
February 2025
Department of Radiology, Netherlands Cancer Institute- Antoni van Leeuwenhoekziekenhuis, Amsterdam, The Netherlands.
Background: Small-molecule biomacromolecules target tumor-specific antigens. They are employed as theranostic agents for imaging and treatment. Intravenous small-molecule radioligands exhibit rapid tumor uptake and excretion.
View Article and Find Full Text PDFPressure-Enabled Drug Delivery Significantly Increases Intra-Arterial Delivery of Embolic Microspheres to Liver Tumors in a Porcine Model.
J Vasc Interv Radiol
November 2024
TriSalus Life Sciences, Westminster, Colorado.
This study aimed to test the hypothesis that pressure-enabled drug delivery (PEDD) with a pressure-modulating microcatheter device (TriNav; TriSalus Life Sciences, Westminster, Colorado) would increase delivery of microspheres via hepatic arterial infusion to liver tumors in an Oncopig model (Sus Clinicals, Chicago, Illinois) when compared with a conventional end-hole microcatheter. Trisacryl gelatin microspheres (100-300 μm in size) were fluorescently labeled and infused into porcine liver tumors using conventional technique (n = 8) or by PEDD (n = 8). Liver tissue was harvested, and images were analyzed with a custom deep learning algorithm (Visiopharm, Hørsholm, Denmark) to quantitate signal intensity.
View Article and Find Full Text PDFIntensive blood pressure lowering in acute stroke with intracranial stenosis post-thrombectomy: A secondary analysis of the OPTIMAL-BP trial.
Int J Stroke
January 2025
Department of Neurology, College of Medicine, Yonsei University, Seoul, Korea.
Background: Intensive blood pressure (BP) management within 24 h after successful reperfusion following endovascular thrombectomy (EVT) is associated with worse functional outcomes than conventional BP management in Asian randomized controlled trials. Given the high prevalence of intracranial atherosclerotic stenosis (ICAS) in Asia, ICAS may influence these outcomes.
Aims: We aimed to assess whether ICAS affects the outcomes of intensive BP management after successful EVT.
Bevacizumab: The future of chronic subdural hematoma.
Interv Neuroradiol
November 2024
Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Bevacizumab (BCZ), commercially known as Avastin, is a monoclonal antibody that targets vascular endothelial growth factor (VEGF). Initially recognized as a breakthrough in oncology, it has since gained FDA approval for various ocular conditions and more recently, for the treatment of glioblastoma multiforme (GBM). Bevacizumab's ability to inhibit excessive neovascularization suggests it may have a potential role in treating chronic subdural hematomas (cSDH).
View Article and Find Full Text PDFFacial Artery Branch Thrombolysis for Nasal Vascular Embolism Induced by Hyaluronic Acid Injection.
Ann Plast Surg
December 2024
From the Department of Aesthetic Medicine, The Third People's Hospital of Chengdu (Affiliated Hospital of Southwest Jiaotong University), College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China.
Background: Vascular embolism is a severe complication following hyaluronic acid (HA) filler injections, with hyaluronidase injection being the most effective treatment. The nasal region, including the nose and nasolabial fold, is the most common site of vascular embolism after facial HA injections. Currently, there is insufficient clinical evidence regarding the benefits of facial artery thrombolysis.
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