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Mechanistic Investigations of the Mitochondrial Complex I Inhibitor Rotenone in the Context of Pharmacological and Safety Evaluation.
Sci Rep
April 2017
Bayer AG, Drug Discovery, Pharmaceuticals, Wuppertal, Germany.
Inhibitors of the mitochondrial respiratory chain complex I are suggested to exert anti-tumor activity on those tumors relying on oxidative metabolism and are therefore of interest to oncology research. Nevertheless, the safety profile of these inhibitors should be thoroughly assessed. Rotenone, a proven complex I inhibitor, has shown anti-carcinogenic activity in several studies.
View Article and Find Full Text PDFExistence, numerical convergence and evolutionary relaxation for a rate-independent phase-transformation model.
Philos Trans A Math Phys Eng Sci
April 2016
Weierstraß-Institut für Angewandte Analysis und Stochastik, Mohrenstraße 39, 10117 Berlin, Germany
We revisit the model for a two-well phase transformation in a linearly elastic body that was introduced and studied in Mielke et al. (2002 Arch. Ration.
View Article and Find Full Text PDFThe selection and function of cell type-specific enhancers.
Nat Rev Mol Cell Biol
March 2015
1] Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, California 92093, USA. [2] Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, San Diego, California 92093, USA.
The human body contains several hundred cell types, all of which share the same genome. In metazoans, much of the regulatory code that drives cell type-specific gene expression is located in distal elements called enhancers. Although mammalian genomes contain millions of potential enhancers, only a small subset of them is active in a given cell type.
View Article and Find Full Text PDFInfluence of quercetin supplementation on disease risk factors in community-dwelling adults.
J Am Diet Assoc
April 2011
Appalachian State University, Kannapolis, NC, USA.
Background: In vitro data indicate quercetin has antioxidative and anti-inflammatory functions with the potential to lower disease risk factors, but data in human beings are limited.
Objective: The objective of this study was to investigate the effect of quercetin, vitamin C, and niacin supplements (500 mg quercetin, 125 mg vitamin C, and 5 mg niacin [Q-500]; 1,000 mg quercetin, 250 mg vitamin C, and 10 mg niacin [Q-1,000]), on disease risk factors in a large group of community adults (n=1,002, 60% women) varying widely in age and body mass index.
Design: Subjects were randomized into one of three groups (placebo, Q-500, or Q-1,000) and ingested supplements for 12 weeks.
A 12-week supplementation with quercetin does not affect natural killer cell activity, granulocyte oxidative burst activity or granulocyte phagocytosis in female human subjects.
Br J Nutr
September 2010
Department of Biology, Appalachian State University, Boone, NC, USA.
Quercetin, a flavonoid found in fruits and vegetables, is a strong antioxidant with anti-inflammatory, antimicrobial and immune-modulating properties. The purpose of the present study was to investigate the effects of long-term quercetin supplementation on innate immune function and inflammation in human subjects. Female subjects (n 120; aged 30-79 years) were recruited from the community and randomised to one of three groups, with supplements administered using double-blinded procedures: 500 mg quercetin/d (n 38), 1000 mg quercetin/d (n 40) or placebo (n 42).
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