AI Article Synopsis
- The study aimed to assess the quality of life of patients with non-metastatic colorectal cancer receiving two different chemotherapy regimens: FOLFOX and XELOX.
- Over a 24-month period, patients completed the EORTC QLQ-C30 questionnaire at the start and after 12 weeks of treatment to evaluate various health and emotional factors.
- Results indicated that while FOLFOX patients reported better emotional well-being, those on XELOX experienced more severe symptoms such as fatigue, nausea, and diarrhea, suggesting differing impacts on quality of life between the two treatments.
Article Abstract
Objective: To evaluate and to compare quality of life of patients with non- metastasic colorectal cancer treated either with FOLFOX or with XELOX scheme.
Method: Descriptive prospective study during 24 months (October 2015- October 2017) for patients with non-metastasic colorectal cancer in chemotherapy adyuvant treatment. EORTC QLQ-C30 questionnaire was filled by patients at the beginning and at week 12 of adjuvant treatment. Variables collected: exposure (chemotherapeutic scheme administered), control (demographic data, disease data, treatment data) and response (scores obtained from the questionnaire). The data statistical analysis was carried out with the SPSS® 15.0 programme.
Results: 30 patients were included. Statistically significant differences were found in emotional role item at the middle of the treatment (FOLFOX 92 points vs. XELOX 82 points; p = 0,036). Patients with FOLFOX presented a clinically relevant worsening in terms of daily activities, constipation and insomnia. Patients treated with XELOX a clinically relevant worsening in daily activities, constipation, fatigue, nausea, vomiting, anorexia and diarrhoea were observed.
Conclusions: Patients with XELOX scheme referred to have worse emotionally status in the middle of the adjuvant treatment than patients treated with FOLFOX scheme and presented a worsening in items fatigue, nausea, vomiting, anorexia and diarrhoea.
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| http://dx.doi.org/10.7399/fh.11156 | DOI Listing |
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