AI Article Synopsis
- Psoriasis is an inflammatory skin condition that increases the risk of cardiovascular issues and is a useful model for studying inflammation-related heart disease.
- The study highlights the connection between low-density granulocytes (a type of neutrophil) and platelets, specifically how their interaction is linked to the presence of noncalcified coronary plaques measured by coronary CT angiography.
- Since the presence of noncalcified plaques can lead to serious heart attacks, targeting the interaction between low-density granulocytes and platelets could be important for future clinical treatments.
Article Abstract
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study inflammatory atherogenesis. Because neutrophils are implicated in atherosclerosis development, this study reports that the interaction among low-density granulocytes, a subset of neutrophils, and platelets is associated with a noncalcified coronary plaque burden assessed by coronary computed tomography angiography. Because early atherosclerotic noncalcified burden can lead to fatal myocardial infarction, the low-density granulocyte-platelet interaction may play a crucial target for clinical intervention.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390681 | PMC |
| http://dx.doi.org/10.1016/j.jacbts.2018.10.008 | DOI Listing |
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