Poorly differentiated cutaneous squamous cell carcinoma with osteoclast-like giant cell: A rare, aggressive variant.

Clin Case Rep

Anatomical Pathology Douglass Hanly Moir Pathology Sydney New South Wales Australia.

Published: February 2019

Squamous Cell Carcinoma (SCC) with Osteoclast-like giant cell (OLGC) is a rare SCC variant; only 10 cases have been reported. Our case suggests OLGC are resultant of a reactive process, driven by the fusion of adjacent macrophages. Knowledge regarding SCC with OLGC is of great importance as this entity has greater prometastatic potential compared to conventional SCC.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389463PMC
http://dx.doi.org/10.1002/ccr3.1955DOI Listing

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