AI Article Synopsis
- The study investigates the expression of Keratin 15 (K15) in various odontogenic lesions, namely dentigerous cysts, odontogenic keratocysts, and ameloblastomas.
- The research included 41 samples, using immunohistochemistry to analyze K15 expression, which was found to be present in most lesions without significant differences among them.
- The findings suggest that while K15 shows high expression in these lesions, it may not serve as a reliable stem cell marker, but could indicate abnormal differentiation in the epithelial cells of the lesions.
Article Abstract
The etiology and pathogenesis of odontogenic lesions are poorly understood. Keratin 15 (K15) is a type I cytoskeletal protein that provides structural support to the cells and has been considered to be a stem cell marker. The aim of the present study was to evaluate the expression of K15 in the epithelial lining of dentigerous cysts (DCs), odontogenic keratocysts (OKCs) and ameloblastomas (ABs). The study included 41 samples of DCs (n=13), OKCs (n=12), and AB tissues (n=16). K15 protein expression was evaluated via immunohistochemistry and data were statistically analyzed using a Kruskal-Wallis test. K15 was expressed in the majority of the studied lesions with various distributions in the different study samples. The Kruskal-Wallis test revealed non-significant differences in the expression of K15 among the three odontogenic lesions (P=0.380). The present study confirmed the high expression of K15 in the different epithelial layers of DC, OKC and AB. This type of expression excludes the reliability of regarding K15 as a stem cell marker in DC, OKC and AB. However, K15 may reflect the abnormal differentiation of pathological epithelial cells in these lesions.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388503 | PMC |
| http://dx.doi.org/10.3892/mco.2019.1802 | DOI Listing |
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