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| http://dx.doi.org/10.1016/j.chest.2018.09.032 | DOI Listing |
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Boldine reduces left ventricle oxidative stress in isoproterenol-induced adrenergic overload experimental model.
Arch Physiol Biochem
December 2024
Laboratory of Cardiovascular Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil.
Article Synopsis
- Sustained adrenergic overload can lead to harmful changes in the heart, characterized by oxidative stress, which can worsen heart function.
- Boldine (BOL), an antioxidant, was tested for its potential to protect the heart from damage caused by isoproterenol (ISO) in a rat study.
- Results showed that BOL significantly reduced heart enlargement and improved oxidative stress markers compared to ISO alone, suggesting it could be a beneficial treatment for adverse cardiac changes.
Isoproterenol mechanisms in inducing myocardial fibrosis and its application as an experimental model for the evaluation of therapeutic potential of phytochemicals and pharmaceuticals.
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Department of Pharmacology and Therapeutics, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.
Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fibrosis, which appears to be a leading cause of cardiovascular diseases. Cardiac fibrosis is characterized by the accumulation of extracellular matrix proteins, mainly collagen in the cardiac interstitium. Many experimental studies have demonstrated that fibrotic injury in the heart is reversible; therefore, it is vital to understand different molecular mechanisms that are involved in the initiation, progression, and resolution of cardiac fibrosis to enable the development of antifibrotic agents.
View Article and Find Full Text PDFDobutamine induced multifocal myoclonus in a patient with chronic kidney disease.
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Department of Cardiac Thoracic and Vascular Anesthesia, JSS Medical college and Hospital, Mysore, Karnataka, India.
Adverse drug reactions (ADRs) are common in clinical practice, especially among patients with multiple comorbidities and polypharmacy. The ADRs associated with medications may be minor or life-threatening. Many available ADR assessment scales and pharmacovigilance programmes have streamlined the early diagnosis and management of ADRs.
View Article and Find Full Text PDFImpact of boldine treatment on hypertrophy and lipid peroxidation in the right ventricle subjected to experimental adrenergic overstimulation.
J Cardiovasc Pharmacol
December 2024
Laboratory of Cardiovascular Physiology, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, RS, Brasil.
Adrenergic overstimulation is detrimental to the left ventricle. However, its effects on the right ventricle (RV) are not clear. Since adrenergic overload increases metabolic demand and oxidative stress, boldine could be a therapeutic option in the treatment of cardiovascular disease due to its antioxidant role.
View Article and Find Full Text PDFβ-adrenergic regulation of Ca signaling in heart cells.
Biophys Rep
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Cyrus Tang Medical Institute, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, Jiangsu 215123, China.
β-adrenergic receptors (βARs) play significant roles in regulating Ca signaling in cardiac myocytes, thus holding a key function in modulating heart performance. βARs regulate the influx of extracellular Ca and the release and uptake of Ca from the sarcoplasmic reticulum (SR) by activating key components such as L-type calcium channels (LTCCs), ryanodine receptors (RyRs) and phospholamban (PLN), mediated by the phosphorylation actions by protein kinase A (PKA). In cardiac myocytes, the presence of βAR provides a protective mechanism against potential overstimulation of βAR, which may aid in the restoration of cardiac dysfunctions.
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