AI Article Synopsis
- - Squamous cell carcinoma (SCC) is a challenging type of cancer that can develop in various body parts, including the esophagus, head and neck, lungs, and skin, and is known for being resistant to treatments.
- - Key genetic changes in SCC lead to the activation of ΔNp63, an oncogene that promotes tumor growth by influencing certain genetic programs that support cancer cell survival.
- - The review highlights the genetic and epigenetic factors that enhance ΔNp63's oncogenic role in SCC and examines how this affects interactions between tumor cells and their surrounding environment.
Article Abstract
Squamous cell carcinoma (SCC) is a treatment-refractory tumour which arises from the epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin. Accumulating evidence has revealed a number of genomic, clinical and molecular features commonly observed in SCC of distinct origins. Some of these genetic events culminate in fostering the activity of ΔNp63, a potent oncogene which exerts its pro-tumourigenic effects by regulating specific transcriptional programmes to sustain malignant cell proliferation and survival. In this review, we will describe the genetic and epigenetic determinants underlying ΔNp63 oncogenic activities in SCC, and discuss some relevant transcriptional effectors of ΔNp63, emphasizing their impact in modulating the crosstalk between tumour cells and tumour microenvironment (TME).
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487733 | PMC |
| http://dx.doi.org/10.1002/1878-0261.12473 | DOI Listing |
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