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Next step towards point-of-care molecular diagnosis of female genital schistosomiasis (FGS): evaluation of an instrument-free LAMP procedure.
Front Parasitol
May 2024
Department of Parasitology, Leiden University Medical Center, Leiden, Netherlands.
Detection of spp. DNA in gynaecological samples by quantitative real-time polymerase chain reaction (qPCR) is considered to be the reference diagnostic test for female genital schistosomiasis (FGS). However, qPCR needs expensive laboratory procedures and highly trained technicians.
View Article and Find Full Text PDFThe conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Spain and co-rapporteur Member State Germany for the pesticide active substance phosphine are reported. The context of the peer review was that required by Commission Implementing Regulation (EU) No 844/2012. The conclusions were reached on the basis of the evaluation of the representative uses of phosphine as a post-harvest indoor insecticide to control insects infesting stored grains (barley, oat, rye, wheat), cacao and coffee beans, tree nuts and oilseeds and dried fruit via gassing application (gas-tight rooms/container).
View Article and Find Full Text PDFPoint prevalence survey to assess antibiotic prescribing pattern among hospitalized patients in a county referral hospital in Kenya.
Front Antibiot
October 2022
Directorate of Grant and Development, Mount Kenya University, Thika, Kenya.
Antibiotic resistance causes higher morbidity and mortality and higher healthcare costs. One of the factors influencing the emergence of antibiotic resistance is the inappropriate use of antibiotics. Clinical practitioners' incorrect prescription patterns and a disregard for antibiotic usage recommendations are the leading causes of this resistance.
View Article and Find Full Text PDFAssociation between patient perception of disease status and different components of the Minimal Disease Activity (MDA) criteria in psoriatic arthritis.
J Rheumatol
January 2025
Laura C Coates BM BCh PhD, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Objective: The aim of this analysis was to evaluate the relationship between the criteria met of the Minimal Disease Activity (MDA) score for psoriatic arthritis (PsA) and patient-perceived disease status.
Methods: We analysed data from the ReFlaP study (NCT03119805), a cross-sectional international study of adult patients with PsA. Patients self-reported if they felt their PsA was in remission (REM), low disease activity (LDA) or neither.
Data Treatment for LC-MS Untargeted Analysis.
Methods Mol Biol
January 2025
Research and Innovation Centre, Fondazione E. Mach, Trento, Italy.
Liquid Chromatography-Mass Spectrometry (LC-MS) untargeted experiments require complex bioinformatic strategies to extract information from the experimental data. Here we discuss the "data preprocessing," the set of procedures performed on the raw data to produce a data matrix which will be the starting point for the subsequent statistical analysis. Data preprocessing is a crucial step on the path to knowledge extraction, which should be carefully controlled and optimized in order to maximize the output of any untargeted metabolomics investigation.
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