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http://dx.doi.org/10.2196/13636 | DOI Listing |
Zookeys
August 2024
Department of Life Sciences, National Chung Hsing University, Taichung, Taiwan National Chung Hsing University Taichung Taiwan.
[This corrects the article DOI: 10.3897/zookeys.1196.
View Article and Find Full Text PDFFront Toxicol
April 2024
Instem, Conshohocken, PA, United States.
The ICH S1B carcinogenicity global testing guideline has been recently revised with a novel addendum that describes a comprehensive integrated Weight of Evidence (WoE) approach to determine the need for a 2-year rat carcinogenicity study. In the present work, experts from different organizations have joined efforts to standardize as much as possible a procedural framework for the integration of evidence associated with the different ICH S1B(R1) WoE criteria. The framework uses a pragmatic consensus procedure for carcinogenicity hazard assessment to facilitate transparent, consistent, and documented decision-making and it discusses best-practices both for the organization of studies and presentation of data in a format suitable for regulatory review.
View Article and Find Full Text PDFJMIR Nurs
October 2023
Dalla Lana School of Public Health, University of Toronto, Institute for Health Policy, Management, & Evaluation, Toronto, ON, Canada.
[This corrects the article DOI: 10.2196/22118.].
View Article and Find Full Text PDFJ Pediatr Surg
July 2023
Mercer University School of Medicine, Columbus Campus, Columbus, GA, USA. Electronic address:
The descent of the testis and the development of an inguinal hernia were the earliest published scientific work by John Hunter, the Scottish surgeon and anatomist who is acknowledged as the father of scientific surgery. Hunter's anatomic descriptions are the ones we use today to describe the prenatal descent of the testis and to explain the pathogenesis of an undescended testis and inguinal hernia in infancy. His work appeared in print in 1762, not as a formal publication but as an addendum to a screed written by his older brother William publicly accusing Percival Pott of pirating John's observations on the pathogenesis of an inguinal hernia and publishing them as his own, an early example of scientific rivalry.
View Article and Find Full Text PDFJ Am Coll Radiol
April 2023
Vice Chair, Radiology Quality and Safety, Mass General Brigham; Vice Chair, Department of Radiology; Distinguished Chair, Medical Informatics; Director, Center for Evidence Based Imaging; Department of Radiology, Center for Evidence-Based Imaging, Brigham and Women's Hospital, Boston, Massachusetts; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; and Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Objective: Determine the rate of documented notification, via an alert, for intra-institutional discrepant radiologist opinions and addended reports and resulting clinical management changes.
Methods: This institutional review board-exempt, retrospective study was performed at a large academic medical center. We defined an intra-institutional discrepant opinion as when a consultant radiologist provides a different interpretation from that formally rendered by a colleague at our institution.
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