AI Article Synopsis
- - A new, easy method has been created to prepare different functional cycloalkynes, including those integrated with proteins, using azides as starting materials
- - The process involves treating diynes with a copper salt to selectively react terminal alkynes with azides
- - Additionally, a more reactive strained alkyne is temporarily protected from reacting by forming a complex with copper, allowing for better control in the synthesis
Article Abstract
A facile method for preparing various functional cycloalkynes, including proteins incorporated with a cycloalkyne moiety, from the corresponding azides is developed. Treatment of diynes bearing strained and terminal alkyne moieties with a copper salt enabled terminal alkyne-selective click conjugation with azides, whereas a more azidophilic strained alkyne moiety was transiently protected from the click reaction via complexation with copper.
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| http://dx.doi.org/10.1039/c9cc01113g | DOI Listing |
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