A quick access tool for the one-pot, chromatography-free synthesis of the diversified dihydrospiro[indeno[1,2-b]pyridine-4,3'-indoline or acenaphthylene-1,4'-indeno[1,2-b]pyridine spiro-analogous via sustainable microwave condition in minimal 1:1 (v/v) aqueous ethanol without any metal catalyst is demonstrated here. This permutated spiro-casing was designed as fluorescence probe at physiological pH for selective detection of Zn, even in the presence of other competitive ions and showed a fluorescent enhancement with 1:1 metal/ligand complex. Moreover, this spiro sensor was successfully applied as an effective intracellular Zn imaging agent in the biomedical study of human hepatocellular liver carcinoma cells (HepG2) due to its cell permeability property. A quick access technique for the permutated dihydrospiro-pyridine via chromatography-free sustainable microwave condition and its applications as organic fluorescence probe at physiological pH for selective detection of Zn and effective intracellular Zn imaging in HepG2 cells.
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