AI Article Synopsis
- The Rho kinase (ROCK) signaling pathway influences key cellular processes like cell growth and structure, especially in the eye.
- ROCK's role in corneal endothelial health and its impact on the outflow of fluid in glaucomatous conditions have made it a focus for new drug development.
- The article reviews existing research on ROCK's involvement in eye diseases and discusses the potential benefits of ROCK inhibitors in treating these conditions.
Article Abstract
The Rho kinase (ROCK) signaling pathway is involved in several cellular events that include cell proliferation and cytoskeleton modulation leading to cell adhesion. The ROCK pathway in the human eye has been hypothesized to play important roles in corneal endothelial cell physiology and pathologic states. In addition, ROCK signaling has been identified as an important regulator of trabecular meshwork (TM) outflow, which is altered in glaucomatous eyes. These roles in corneal and glaucomatous disease states have led to the growing interest in the development of drugs selectively targeting this pathway (ROCK inhibitors). The authors provide a review of the literature on the pathobiology of the ROCK signaling in corneal endothelial disease, glaucoma, and vitreoretinal disease, as well as the clinical usefulness of ROCK inhibitors in Ophthalmology.
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| http://dx.doi.org/10.1007/s00417-019-04283-5 | DOI Listing |
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