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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403056 | PMC |
| http://dx.doi.org/10.1093/schbul/sby074 | DOI Listing |
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The essential role of MED27 in stabilizing the mediator complex for cardiac development and function.
Life Sci
November 2024
Department of Cardiovascular Surgery, Peking University Shenzhen Hospital, School of Chemical Biology and Biotechnology, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen, China. Electronic address:
Aim: Transcriptional regulation of gene expression plays a crucial role in orchestrating complex morphogenetic and molecular events during heart development and function. Mediator complex is an essential multi-subunit protein complex that governs gene expression in eukaryotic cells. Although Mediator subunits (MEDs) work integrally in the complex, individual MED component displays specialized functions.
View Article and Find Full Text PDFA New Test for the Advanced Diagnosis of Lateral Elbow Tendinopathy with Concomitant Intrasubstance Tear: Failure to Resist Extension Effort (the Free Test).
Orthop Res Rev
December 2022
Centro de Medicina Ejercicio Deporte y Salud, Clínica MEDS, Santiago, Chile.
Background: Lateral elbow tendinopathy (LET) is one of the most common causes of musculoskeletal pain. The diagnosis is based on the clinical history and different physical maneuvers. Ultrasound (US) is a complementary diagnostic method to detect degenerative tendon changes and intrasubstance tears (IST).
View Article and Find Full Text PDFSteadiness training improves the quadriceps strength and self-reported outcomes in persistent quadriceps weakness following nine months of anterior cruciate ligament reconstruction and failed conventional physiotherapy.
Clin Biomech (Bristol)
February 2022
Laboratory of Neuromechanics, Universidade Federal do Pampa, Uruguaiana, Brazil. Electronic address:
Background Persistent quadriceps weakness may occur after anterior cruciate ligament reconstruction, limiting the strength gain. However, steadiness strengthening might change the inability to gain strength. Hence, we determined whether strength training with force steadiness and visual biofeedback can improve knee quadriceps torque, self-reported pain and knee stability in patients with persistent quadriceps weakness after knee anterior cruciate ligament reconstruction.
View Article and Find Full Text PDFP053 Interstitial Nephritis from IBD: Complicated Conclusions.
Am J Gastroenterol
December 2021
University of Rochester Medical Center, Rochester, Minnesota, United States.
Article Synopsis
- The case study discusses three patients with tubulointerstitial nephritis (TIN) linked to inflammatory bowel disease (IBD), showcasing the complexities in identifying the underlying causes of their kidney injuries.
- In Case #1, a 58-year-old male with Crohn's disease experienced acute kidney injury after transitioning medications, with a biopsy suggesting possible drug-induced hypersensitivity or a manifestation of IBD.
- Cases #2 and #3 involved a female with ulcerative colitis and a male who had latent TB, both developing TIN under various treatments, highlighting that kidney injury could stem from either IBD itself or their medications.
Extended-release naltrexone for youth with opioid use disorder.
J Subst Abuse Treat
November 2021
Friends Research Institute, 1040 Park Avenue, Suite, 103 Baltimore, MD, USA. Electronic address:
Background: Few published research studies have examined the effectiveness of extended-release naltrexone (XR-NTX) for the treatment of opioid use disorder (OUD) among adolescents and young adults.
Methods: This two-group randomized controlled trial recruited 288 youth, ages 15-21, with moderate/severe OUD from a residential addiction treatment program in Baltimore, Maryland. The study randomized the youth within the first week of treatment entry to receive either XR-NTX or treatment-as-usual (TAU; either buprenorphine maintenance treatment or treatment without OUD medication following medically managed withdrawal) prior to discharge, with continued treatment in the community for 6 months.
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