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| http://dx.doi.org/10.1212/WNL.0000000000007240 | DOI Listing |
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Responsive neurostimulation of thalamic nuclei for regional and multifocal drug-resistant epilepsy in children and young adults.
J Neurosurg Pediatr
July 2024
1Department of Pediatrics, Division of Neurology and Developmental Neuroscience, Texas Children's Hospital, Baylor College of Medicine, Houston, Texas.
Objective: Responsive neurostimulation (RNS) is a US FDA-approved form of neuromodulation to treat patients with focal-onset drug-resistant epilepsy (DRE) who are ineligible for or whose condition is refractory to resection. However, the FDA approval only extends to use in patients with one or two epileptogenic foci. Recent literature has shown possible efficacy of thalamic RNS in patients with Lennox-Gastaut syndrome and multifocal epilepsy.
View Article and Find Full Text PDFVagus Nerve Stimulation Modulates Phase-Amplitude Coupling in Thalamic Local Field Potentials.
Neuromodulation
April 2023
Division of Neurosurgery, Hospital for Sick Children, Toronto, Ontario, Canada; Department of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada; Department of Neuroscience and Mental Health, Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:
Objective: The antiseizure effects of vagus nerve stimulation (VNS) are thought to be mediated by the modulation of afferent thalamocortical circuitry. Cross-frequency phase-amplitude coupling (PAC) is a mechanism of hierarchical network coordination across multiple spatiotemporal scales. In this study, we leverage local field potential (LFP) recordings from the centromedian (CM) (n = 3) and anterior (ATN) (n = 2) nuclei in five patients with tandem thalamic deep brain stimulation and VNS to study neurophysiological changes in the thalamus in response to VNS.
View Article and Find Full Text PDFDural arteriovenous fistula, a rare cause of rapidly progressive dementia in a patient with bilateral thalamic lesions: a case report.
Ann Palliat Med
July 2021
Department of Neurology, Peking University First Hospital, Beijing, China.
There are many causes of bilateral thalamic lesions, but few cases of dural arteriovenous fistula (DAVF) associated with such lesions have been reported previously. Here, we describe an adult man with reversible rapid progressive dementia (RPD) in whom bilateral thalamic lesions were caused by a DAVF that had six supply arteries and drained into both the venous sinus and cortical veins. A 53-year-old man presented with memory decline and abnormal behavior.
View Article and Find Full Text PDFWidespread subcortical grey matter degeneration in primary lateral sclerosis: a multimodal imaging study with genetic profiling.
Neuroimage Clin
September 2020
Computational Neuroimaging Group, Biomedical Sciences Institute, Trinity College Dublin, 152-160 Pearse Street, Dublin 2, Ireland. Electronic address:
Background: Primary lateral sclerosis (PLS) is a low incidence motor neuron disease which carries a markedly better prognosis than amyotrophic lateral sclerosis (ALS). Despite sporadic reports of extra-motor symptoms, PLS is widely regarded as a pure upper motor neuron disorder. The post mortem literature of PLS is strikingly sparse and very little is known of subcortical grey matter pathology in this condition.
View Article and Find Full Text PDFCortical and bithalamic hypometabolism by FDG-PET/CT in a patient with sporadic fatal insomnia.
Neurology
April 2019
From Johns Hopkins School of Medicine (T.H., C.M., L.S., J.C.P.), Baltimore, MD; Case Western Reserve University School of Medicine (M.C., J.S.), Cleveland, OH; and National Center for Emerging and Zoonotic Infectious Diseases (L.B.S.), Centers for Disease Control and Prevention, Atlanta, GA.
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