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Lutetium-177 DOTATATE Therapy and Cardiac Outcomes in Patients With Neuroendocrine Tumor and Cardiac Metastases.
JACC CardioOncol
December 2024
Department of Cardiovascular Medicine, Mayo Clinic, Phoenix, Arizona, USA.
Targeting BMP-1 enhances anti-tumoral effects of doxorubicin in metastatic mammary cancer: common and distinct features of TGF-β inhibition.
Breast Cancer Res Treat
January 2025
Department of Oncology, University of Torino, Via Nizza 44, 10126, Turin, Italy.
Article Synopsis
- Mammary carcinoma consists of different cell types with varying abilities to spread, and a specific type of cell (4T1) was identified as highly metastatic, influenced by TGF-β and BMP-1.
- Researchers found that inhibiting BMP-1 not only reduced cancer cell growth but also improved the effectiveness of the chemotherapy drug doxorubicin.
- This study highlights the potential of targeting BMP-1 as a promising therapeutic strategy for treating aggressive metastatic breast cancer.
Cardiac metastasis of a soft tissue sarcoma: Case report and review of literature.
Acta Radiol Open
January 2025
Radiology Department, Mohammed VI University Hospital, Tangier, Morroco.
Cardiac metastases are the most frequent cardiac tumors. They can cause dysrhythmia, myocardial dysfunction, pericardial effusion, and heart failure. In decreasing order, the major primary malignancies associated with cardiac metastases are pleural mesothelioma, lung adenocarcinoma, undifferentiated carcinomas, lung squamous cell carcinoma, and breast carcinoma.
View Article and Find Full Text PDFNon-oncologic metastases.
Eur Heart J
January 2025
Radiology Service, Complexo Hospitalario Universitario de Pontevedra, Spain.
Cardiovascular Disease and Cancer: A Dangerous Liaison.
Arterioscler Thromb Vasc Biol
January 2025
Cardiovascular Research Center, New York University Langone Health, New York University Grossman School of Medicine. (A.A.C.N., J.M.D., K.J.M.).
The field of cardio-oncology has traditionally focused on the impact of cancer and its therapies on cardiovascular health. Mounting clinical and preclinical evidence, however, indicates that the reverse may also be true: cardiovascular disease can itself influence tumor growth and metastasis. Numerous epidemiological studies have reported that individuals with prevalent cardiovascular disease have an increased incidence of cancer.
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