AI Article Synopsis
- The study focuses on understanding how the mechanical properties of skin tissue at a larger scale are influenced by the arrangement of collagen fibers at a smaller scale.
- The researchers developed a protocol that combines traction assays and multiphoton microscopy to analyze ex vivo (outside the body) murine (mouse) skin samples.
- This approach allows for the simultaneous observation of skin's stress/stretch responses and the collagen reorganization in the dermis through second harmonic generation (SHG) imaging techniques.
Article Abstract
An important issue in tissue biomechanics is to decipher the relationship between the mechanical behavior at macroscopic scale and the organization of the collagen fiber network at microscopic scale. Here, we present a protocol to combine traction assays with multiphoton microscopy in ex vivo murine skin. This multiscale approach provides simultaneously the stress/stretch response of a skin biopsy and the collagen reorganization in the dermis by use of second harmonic generation (SHG) signals and appropriate image processing.
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| http://dx.doi.org/10.1007/978-1-4939-9095-5_11 | DOI Listing |
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