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A Biomimetic Model for Mineralization of Type-I Collagen Fibrils. | LitMetric

A Biomimetic Model for Mineralization of Type-I Collagen Fibrils.

Methods Mol Biol

Department of Chemistry, Center for Biomaterials and Biopathways, Zhejiang University, Hangzhou, Zhejiang, China.

Published: August 2019

AI Article Synopsis

Article Abstract

The bone and dentin mainly consist of type-I collagen fibrils mineralized by hydroxyapatite (HAP) nanocrystals. In vitro biomimetic models based on self-assembled collagen fibrils have been widely used in studying the mineralization mechanism of type-I collagen. In this chapter, the protocol we used to build a biomimetic model for the mechanistic study of type-I collagen mineralization is described. Type-I collagen extracted from rat tail tendon or horse tendon is self-assembled into fibrils and mineralized by HAP in vitro. The mineralization process is monitored by cryoTEM in combination with two-dimensional (2D) and three-dimensional (3D) stochastic optical reconstruction microscopy (STORM), which enables in situ and high-resolution visualization of the process.

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Source
http://dx.doi.org/10.1007/978-1-4939-9095-5_4DOI Listing

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