We prove Luzin - and Morse-Sard properties for mappings of the Sobolev-Lorentz class , (this is the sharp case that guaranties the continuity of mappings). Our main tool is a new trace theorem for Riesz potentials of Lorentz functions for the limiting case . Using these results, we find also some very natural approximation and differentiability properties for functions in with exceptional set of small Hausdorff content.
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http://dx.doi.org/10.1007/s12220-017-9936-7 | DOI Listing |
Viruses
November 2024
Department of Public Health, Ministry of Health, P.O. Box 24923, Kuwait City 13110, Kuwait.
Continuous surveillance is critical for early intervention against emerging novel SARS-CoV-2 variants. Therefore, we investigated and compared the variant-specific evolutionary epidemiology of all the Delta and Omicron sequences collected between 2021 and 2023 in Kuwait. We used Bayesian phylodynamic models to reconstruct, trace, and compare the two variants' demographics, phylogeographic, and host characteristics in shaping their evolutionary epidemiology.
View Article and Find Full Text PDFMethods Mol Biol
January 2025
Allen Discovery Center for Lineage Tracing and Department of Laboratory Medicine & Pathology, University of Washington, Seattle, WA, USA.
Mutations are acquired frequently, such t`hat each cell's genome inscribes its history of cell divisions. Loss of heterozygosity (LOH) accumulates throughout the genome, offering large encoding capacity for phylogenetic inference of cell lineage.In this chapter, we demonstrate a method, using single-cell RNA sequencing, for reconstructing cell lineages from inferred LOH events in a Bayesian manner, annotating the lineage with cell phenotypes, and marking developmental time points based on X-chromosome inactivation.
View Article and Find Full Text PDFSci Rep
December 2024
National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing, 102300, China.
Manganese (Mn) is a known toxicant and an essential trace element, and it plays an important role in various mechanisms in relation to cardiovascular health. However, epidemiological studies of the association between blood Mn and cardiovascular diseases (CVD) among U.S.
View Article and Find Full Text PDFFront Immunol
December 2024
The Department of Cardiovascular Medicine, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, China.
Objective: Epidemiological evidence indicates that trace elements are significantly associated with cardiovascular health. However, its causality and underlying mechanisms remain unclear. Therefore, this study aimed to investigate the causal relationship between trace elements and cardiovascular disease, as well as their potential mechanism of action.
View Article and Find Full Text PDFBull Math Biol
November 2024
Molecular Physiology and Biophysics, University of Iowa, 51 Newton Road, Iowa City, IA, 52242, USA.
Metabolic fluxes are the rates of life-sustaining chemical reactions within a cell and metabolites are the components. Determining the changes in these fluxes is crucial to understanding diseases with metabolic causes and consequences. Kinetic flux profiling (KFP) is a method for estimating flux that utilizes data from isotope tracing experiments.
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