rs3856806 C>T Polymorphism Increased the Risk of Colorectal Cancer: A Case-Control Study in Eastern Chinese Han Population.

Functional variants in the () and () family (e.g., and ) genes were predicted to confer susceptibility to colorectal cancer (CRC). The aim of the present study was to explore the relationship between polymorphism and the risk of CRC. We conducted a case-control study with 1,003 CRC cases and 1,303 controls. We selected the rs3856806 C>T, rs2970847 C>T, rs8192678 C>T, rs3736265 G>A and rs7732671 G>C and rs17572019 G>A SNPs to assess the relationship between their variants and risk of CRC. We found that the rs3856806 C>T polymorphism increased the risk of CRC (TT vs. CC: adjusted OR, 1.59, 95% CI 1.08-2.35, = 0.020; TT/CT vs. CC: adjusted OR, 1.26; 95% CI 1.06-1.49; = 0.009 and TT vs. CC/CT: adjusted OR, 1.54; 95% CI 1.05-2.26; = 0.028), even after a Bonferroni correction test. The stratified analysis revealed that the rs3856806 C>T polymorphism also increased the risk of CRC, especially in male, ≥61 years old, never smoking, never drinking, BMI ≥ 24 kg/m, colon cancer and rectum cancer subgroups. Our findings highlight that the rs3856806 C>T polymorphism may increase the risk of CRC. In the future larger sample size case-control studies with a detailed functional assessment are needed to further determine the relationship of the rs3856806 C>T polymorphism with CRC risk.