A PHP Error was encountered

Severity: Warning

Message: file_get_contents(https://...@gmail.com&api_key=61f08fa0b96a73de8c900d749fcb997acc09): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests

Filename: helpers/my_audit_helper.php

Line Number: 143

Backtrace:

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 143
Function: file_get_contents

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 209
Function: simplexml_load_file_from_url

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 994
Function: getPubMedXML

File: /var/www/html/application/helpers/my_audit_helper.php
Line: 3134
Function: GetPubMedArticleOutput_2016

File: /var/www/html/application/controllers/Detail.php
Line: 574
Function: pubMedSearch_Global

File: /var/www/html/application/controllers/Detail.php
Line: 488
Function: pubMedGetRelatedKeyword

File: /var/www/html/index.php
Line: 316
Function: require_once

Diet in the Driving Seat: Natural Diet-Immunity-Microbiome Interactions in Wild Fish. | LitMetric

Diet in the Driving Seat: Natural Diet-Immunity-Microbiome Interactions in Wild Fish.

Front Immunol

School of Environment and Life Sciences, University of Salford, Salford, United Kingdom.

Published: October 2020

AI Article Synopsis

  • The study investigates the interactions between diet, microbiome, and immunity using wild three-spined sticklebacks as a model, highlighting the lack of prior research in this area.
  • It finds that seasonal variations in diet significantly influence immune responses independent of the microbiome's overall composition and the host's health, suggesting that diet has a direct effect on immunity.
  • Additionally, the research reveals that while diet impacts microbiome composition, certain animal-protein-rich diets may promote the growth of pathogenic bacteria, indicating a complex relationship between diet, immunity, and the microbial community in these fish.

Article Abstract

Natural interactions between the diet, microbiome, and immunity are largely unstudied. Here we employ wild three-spined sticklebacks as a model, combining field observations with complementary experimental manipulations of diet designed to mimic seasonal variation in the wild. We clearly demonstrate that season-specific diets are a powerful causal driver of major systemic immunophenotypic variation. This effect occurred largely independently of the bulk composition of the bacterial microbiome (which was also driven by season and diet) and of host condition, demonstrating neither of these, , constrain immune allocation in healthy individuals. Nonetheless, through observations in multiple anatomical compartments, differentially exposed to the direct effects of food and immunity, we found evidence of immune-driven control of bacterial community composition in mucus layers. This points to the interactive nature of the host-microbiome relationship, and is the first time, to our knowledge, that this causal chain (diet → immunity → microbiome) has been demonstrated in wild vertebrates. Microbiome effects on immunity were not excluded and, importantly, we identified outgrowth of potentially pathogenic bacteria (especially mycolic-acid producing corynebacteria) as a consequence of the more animal-protein-rich summertime diet. This may provide part of the ultimate explanation (and possibly a proximal cue) for the dramatic immune re-adjustments that we saw in response to diet change.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389695PMC
http://dx.doi.org/10.3389/fimmu.2019.00243DOI Listing

Publication Analysis

Top Keywords

diet
7
diet driving
4
driving seat
4
seat natural
4
natural diet-immunity-microbiome
4
diet-immunity-microbiome interactions
4
wild
4
interactions wild
4
wild fish
4
fish natural
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!

A PHP Error was encountered

Severity: Notice

Message: fwrite(): Write of 34 bytes failed with errno=28 No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 272

Backtrace:

A PHP Error was encountered

Severity: Warning

Message: session_write_close(): Failed to write session data using user defined save handler. (session.save_path: /var/lib/php/sessions)

Filename: Unknown

Line Number: 0

Backtrace: